Evidence map›Paper›PMID 29879846›Full record

ArticleAngiology2019

Plasma Galectin-3 and Sonographic Measures of Carotid Atherosclerosis in the Atherosclerosis Risk in Communities Study.

Abayomi Oyenuga, Aaron R Folsom, Oluwaseun Fashanu, David Aguilar, Christie M Ballantyne

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Role of galectin-3 in vascular calcification.Glycoconjugate journal · 2023
    Review
  9. Review
  10. Article
  11. [Balectin-3 affects the stability of vulnerable coronary atherosclerosis plaques by targeted modulation of lncARSR].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021
    Article
  12. Galectin-3 in Cardiovascular Diseases.International journal of molecular sciences · 2020
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Abayomi Oyenuga1 Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-4699-6678
Aaron R Folsom1 Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-2635-2699
Oluwaseun Fashanu2 Department for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA.
David Aguilar3 Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Ciccarone Center, Houston, TX, USA.
Christie M Ballantyne4 Department of Medicine, Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
University of Minnesota · USBaylor College of Medicine · USJohns Hopkins University · USThe University of Texas Health Science Center at Houston · US

Funding

NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005I
6 · The paper itself

Abstract

Galectin-3 is a β-galactoside-binding lectin that plays a role in the regulation of several conditions that are associated with atherosclerosis. The goal of this cross-sectional study was to assess the association of plasma galectin-3 concentrations with sonographic measures of carotid atherosclerosis in the Atherosclerosis Risk in Communities study. Linear regression was used to determine the difference and 95% confidence intervals (CIs) for carotid intima-media thickness (cIMT) by categorical and continuous representations of galectin-3. Logistic regression was used to determine the odds ratio and 95% CI, separately, for dichotomized cIMT (75th percentile = 0.9 mm) and carotid plaque and/or shadowing. Compared to those in the first quintile of galectin-3, those in the fifth quintile of galectin-3 level had higher cIMT (mean difference: 0.020 mm after multivariable adjustment; P trend = .04). Moreover, compared to those in the lowest galectin-3 quintile, those in the highest galectin-3 quintile had higher odds of carotid plaque/and or shadowing (odds ratio 1.13 after multivariable adjustment; P trend = .014). Higher levels of galectin-3 are associated with greater carotid atherosclerosis. Our findings provide support for the role of inflammatory biomarkers in the pathogenesis of atherosclerosis and suggest galectin-3 as a possible target for intervention in the prevention or management of atherosclerotic disease.

Indexed as

AgedBiomarkersBlood ProteinsCarotid ArteriesCarotid Artery DiseasesCarotid Intima-Media ThicknessFemaleGalectin 3GalectinsHumansMaleMiddle AgedPlaque, AtheroscleroticRisk FactorsUltrasonographyBiomarkersBlood ProteinsGalectin 3GalectinsLGALS3 protein, humanARICatherosclerosiscarotid intima–media thicknessgalectin-3plaqueshadowing

Identifiers

PMID29879846
PMCPMC6239970
OpenAlexW2805996811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.