ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2018
Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Human genetic ancestry,eLife · 2026Article
- Addressing key risk factors hindering tuberculosis control activities in West Africa - progress in meeting the UN sustainable development goals.IJID regions · 2025Review
- Molecular determinants of multidrug-resistant tuberculosis in Sierra Leone.Microbiology spectrum · 2024Article
- Opinion review of drug resistant tuberculosis in West Africa: tackling the challenges for effective control.Frontiers in public health · 2024Review
- Genomic and Spatial Analysis on the Recent Transmission ofInfection and drug resistance · 2024Article
- Exploring the role of wastewater-based epidemiology in understanding tuberculosis burdens in Africa.Environmental research · 2023Article
- An overview of tuberculosis outbreaks reported in the years 2011-2020.BMC infectious diseases · 2023Review
- Macrophage susceptibility to infection by GhanaianFrontiers in cellular and infection microbiology · 2023Article
- Low secondary attack rate after prolonged exposure to sputum smear positive miliary tuberculosis in a neonatal unit.Antimicrobial resistance and infection control · 2022Article
- Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns.PLoS pathogens · 2022Review
- Molecular epidemiology and multidrug resistance ofHeliyon · 2021Article
- Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway.BMC infectious diseases · 2021Article
- Assessment of closely related Mycobacterium tuberculosis variants with different transmission success and in vitro infection dynamics.Scientific reports · 2021Article
- Analysis of Mycobacterium africanum in the last 17 years in Aragon identifies a specific location of IS6110 in Lineage 6.Scientific reports · 2021Article
- Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Article
- The Relevance of Genomic Epidemiology for Control of Tuberculosis in West Africa.Frontiers in public health · 2021Review
- Genotypic and phenotypic diversity of Mycobacterium tuberculosis complex genotypes prevalent in West Africa.PloS one · 2021Article
- Bacterial Load Comparison of the Three Main Lineages ofFrontiers in microbiology · 2021Article
- Genetic Diversity inAnnual review of genetics · 2020Review
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11 authors.
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Abstract
objectiveUnderstanding transmission dynamics is useful for tuberculosis (TB) control. A population-based molecular epidemiological study was conducted to determine TB transmission in Ghana.
methodsMycobacterium tuberculosis complex (MTBC) isolates obtained from prospectively sampled pulmonary TB patients between July 2012 and December 2015 were characterized using spoligotyping and standard 15-locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) typing for transmission studies.
resultsOut of 2309 MTBC isolates, 1082 (46.9%) unique cases were identified, with 1227 (53.1%) isolates belonging to one of 276 clusters. The recent TB transmission rate was estimated to be 41.2%. Whereas TB strains of lineage 4 belonging to M. tuberculosis showed a high recent transmission rate (44.9%), reduced recent transmission rates were found for lineages of Mycobacterium africanum (lineage 5, 31.8%; lineage 6, 24.7%).
conclusionsThe study findings indicate high recent TB transmission, suggesting the occurrence of unsuspected outbreaks in Ghana. The observed reduced transmission rate of M. africanum suggests other factor(s) (host/environmental) may be responsible for its continuous presence in West Africa.
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