Evidence map›Paper›PMID 29879391›Full record

SynthesisNeuron2018

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.

Anna Zilverstand, Anna S Huang, Nelly Alia-Klein, Rita Z Goldstein

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04864080 (Transdiagnostic Cognitive Biomarkers), which is not on this map. Cited by 334 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
334citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04864080 narecruitingnot on this mapstarted 2022, after this paper: background citation

Transdiagnostic Cognitive Biomarkers

TypeinterventionalSponsorUniversity of MinnesotaRan2022 to 2027Enrolled45ConditionsPain, DepressionArmsComputer game/task, Health surveys online
3 · Its place in the literature

Who cites it

334 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  16. The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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274 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna ZilverstandDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Anna S HuangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nelly Alia-KleinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Rita Z GoldsteinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: rita.goldstein@mssm.edu.

Funding

ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Using event-related potentials to longitudinally track cue-induced craving incubation in cocaine addicted individualsR01DA041528 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOLDSTEIN, RITA Z · 2016 to 2020
$3.3M
Genes, Brain, and Behavior in Human AggressionR01MH090134 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALIA-KLEIN, NELLY · 2010 to 2014
$3.2M
NIDA NIH HHS R01 DA041528NIDA NIH HHS U01 DA041174NIMH NIH HHS R01 MH090134
6 · The paper itself

Abstract

The impaired response inhibition and salience attribution (iRISA) model proposes that impaired response inhibition and salience attribution underlie drug seeking and taking. To update this model, we systematically reviewed 105 task-related neuroimaging studies (n > 15/group) published since 2010. Results demonstrate specific impairments within six large-scale brain networks (reward, habit, salience, executive, memory, and self-directed networks) during drug cue exposure, decision making, inhibitory control, and social-emotional processing. Addicted individuals demonstrated increased recruitment of these networks during drug-related processing but a blunted response during non-drug-related processing, with the same networks also being implicated during resting state. Associations with real-life drug use, relapse, therapeutic interventions, and the relevance to initiation of drug use during adolescence support the clinical relevance of the results. Whereas the salience and executive networks showed impairments throughout the addiction cycle, the reward network was dysregulated at later stages of abuse. Effects were similar in alcohol, cannabis, and stimulant addiction.

Indexed as

Inhibition, PsychologicalAlcoholismAmphetamine-Related DisordersBrainCuesDecision MakingExecutive FunctionFunctional NeuroimagingHumansMarijuana AbuseMemorySubstance-Related DisorderscocainecravingdependencefMRIheroinmarijuananicotineopioidsmokingyouth

Identifiers

PMID29879391
PMCPMC5995133

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.