Evidence map›Paper›PMID 29879387›Full record

ArticleNeuron2018

Beware of Undertow: Opioid Drugs Generate Additional Waves of Intracellular Signaling.

Dong Wang, Daniel J Berg, Grégory Scherrer

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dong WangDepartment of Anesthesiology, Perioperative and Pain Medicine, Department of Neurosurgery, Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA.
Daniel J BergDepartment of Anesthesiology, Perioperative and Pain Medicine, Department of Neurosurgery, Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA.
Grégory ScherrerDepartment of Anesthesiology, Perioperative and Pain Medicine, Department of Neurosurgery, Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA; New York Stem Cell Foundation - Robertson Investigator, Stanford University, Palo Alto, CA 94304, USA. Electronic address: gs25@stanford.edu.
Neurosciences Institute · US

Funding

Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
Identification of cells and signaling mechanisms underlying opioid analgesia and side effectsR01DA044481 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHERRER, GREGORY · 2017 to 2021
$1.8M
Amygdala mechanisms of pain aversionR01NS106301 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHERRER, GREGORY · 2018 to 2022
$1.3M
NIDA NIH HHS R01 DA044481NINDS NIH HHS R01 NS106301
6 · The paper itself

Abstract

In this issue of Neuron, Stoeber et al. (2018) report a biosensor resolving the spatiotemporal organization of opioid receptor activation in living neurons. They delineate novel signaling mechanisms in endosomes and Golgi differentially engaged by opioid peptides and drugs.

Indexed as

Analgesics, OpioidBiosensing TechniquesNeuronsSignal TransductionAnalgesics, Opioid

Identifiers

PMID29879387
PMCPMC6492023
OpenAlexW2805997309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.