Trial reportPlastic and reconstructive surgery2018
Nipple-Sparing Mastectomy Incisions for Cancer Extirpation Prospective Cohort Trial: Perfusion, Complications, and Patient Outcomes.
Trial report in Plastic and reconstructive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Hemi-Y incision for nipple-sparing mastectomy with immediate implant reconstruction: 10-year outcomes from a single-center series.JPRAS open · 2026Article
- Advanced techniques for mastopexy in patients with ptotic breasts requiring nipple-sparing mastectomy: a narrative review.Gland surgery · 2026Review
- Invited Editorial: Antibiotics and Surgical Site Infection in Expander-Based Breast Reconstruction Trial (ASSERT).Annals of surgical oncology · 2026Article
- Predictors of Complications in Prophylactic Mastectomy and Direct-to-Implant Breast Reconstruction: A Retrospective, Single-Center Study.Journal of clinical medicine · 2026Article
- Surgical Safety of Minimally Invasive Surgery Compared to Conventional Nipple-Sparing Mastectomy: A Meta-Analysis and Systematic Reviews.Journal of breast cancer · 2025Article
- Nipple-Sparing Mastectomy and Infection Risk after Immediate Breast Reconstruction.Journal of the American College of Surgeons · 2025Article
- Long-Term Follow-Up of Surgical Outcomes and Oncological Results of Nipple-Sparing Mastectomy with Immediate Reconstruction Through a Single Axillary Incision with Different Approach Methods.Annals of surgical oncology · 2025Article
- A New Convenient Incision Model of the Nipple-Sparing Mastectomy: Lateralized Parabolic Multiplanar Incision.Aesthetic plastic surgery · 2024Article
- Direct-to-Implant vs Tissue Expander Placement in Immediate Breast Reconstruction: A Prospective Cohort Study.Aesthetic surgery journal · 2024Article
- Predicting Nipple Necrosis with a "Lights-on" Indocyanine Green Imaging System: A Report of Two Patients.Archives of plastic surgery · 2024Article
- Trends and issues in clinical research on satisfaction and quality of life after mastectomy and breast reconstruction: a 5-year scoping review.International journal of clinical oncology · 2023Article
- Strategies to avoid mastectomy skin-flap necrosis during nipple-sparing mastectomy.The British journal of surgery · 2023Article
- Nipple-areolar complex (NAC) or skin flap ischemia necrosis post nipple-sparing mastectomy (NSM)-analysis of clinicopathologic factors and breast magnetic resonance imaging (MRI) features.World journal of surgical oncology · 2023Article
- Comparison of complications according to incision types in nipple-sparing mastectomy and immediate reconstruction.Breast (Edinburgh, Scotland) · 2020Article
- Nipple-coring and purse-string suture technique - A modification of the nipple-sparing risk-reducing mastectomy.JPRAS open · 2020Article
- Mastectomy Incision Design to Optimize Aesthetic Outcomes in Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2020Article
- Oncologic Safety and Outcomes in Patients Undergoing Nipple-Sparing Mastectomy.Journal of the American College of Surgeons · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNipple-sparing mastectomy offers several advantages for women seeking postmastectomy breast reconstruction, but compromised skin and nipple perfusion may lead to skin and nipple necrosis. It is unclear whether the incisional approach contributes to these complications; therefore, the purpose of this study was to compare the impact of incision type on outcomes in patients undergoing nipple-sparing mastectomy.
methodsThis is a prospective cohort study of patients undergoing nipple-sparing mastectomy with prosthetic breast reconstruction through an inframammary fold versus a lateral radial incision. Skin and nipple perfusion as represented by fluorescence intensity, mammometric parameters, patient-reported outcomes, and clinical outcomes were analyzed and compared for the two cohorts, and multivariable logistic regression models were performed to evaluate the effects of covariates on outcomes.
resultsSeventy-nine patients were studied: 55 in the inframammary fold cohort and 24 in the lateral radial cohort. The inframammary fold group had significantly less fluorescence intensity to the inferior (21.9 percent versus 36.9 percent; p = 0.001) and lateral portions of breast skin (23.1 percent versus 40.7 percent; p = 0.003) after reconstruction. Decreased fluorescence intensity was associated with smoking, decreased mean arterial pressure, and greater specimen weight. Postreconstruction breast volumes were increased over preoperative volumes in the inframammary fold group (38.3 percent) versus the lateral radial (31.2 percent) group; however, patients with a lateral radial incision had a greater increase in satisfaction with their breasts and psychosocial well-being.
conclusionsThere are significant differences in patient-reported outcomes and final breast volumes based on the incisional approach to nipple-sparing mastectomy. These data can be used to guide providers and counsel patients considering nipple-sparing mastectomy with prosthetic reconstruction. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.