ArticlePlant biotechnology journal2019
QQS orphan gene and its interactor NF-YC4 reduce susceptibility to pathogens and pests.
Article in Plant biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Antagonistic chromatin regulation of LHY homologs by GmASH2R and GmNF-YC4 fine-tunes soybean flowering time for latitudinal adaptation.Plant communications · 2026Article
- BRANCHED1 acts as a rheostat of Nuclear Factor Y-dependent epigenetic regulation in axillary bud development.Nature communications · 2026Article
- The Regulatory Army of Plant Defense: Transcription Factors in the War for Plant Immunity.International journal of molecular sciences · 2026Review
- Genome-Wide Characterization of Nuclear Factor Y (NF-Y) Transcription Factors in Allohexaploid Oat.Plants (Basel, Switzerland) · 2026Article
- Functional Characterisation of NF-YCs in True Leaf Biomass Accumulation.Plants (Basel, Switzerland) · 2026Article
- The Brassicaceae-restricted geneFrontiers in plant science · 2026Article
- RING-Type E3 Ligase OsRFPH2-6 Ubiquitinates Nuclear Factor Y Subunit OsNF-YA1 to Suppress Rice Immunity.Molecular plant pathology · 2025Article
- Nuclear factor-Y transcription factors in crops: Biological roles, regulation, and breeding applications.Plant communications · 2025Review
- Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis.Molecular biology and evolution · 2025Article
- A module with multiple transcription factors positively regulates powdery mildew resistance in grapevine.Plant biotechnology journal · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- CRISPR/Cas9-based editing of NF-YC4 promoters yields high-protein rice and soybean.The New phytologist · 2025Article
- Article
- A de novo Gene Promotes Seed Germination Under Drought Stress in Arabidopsis.Molecular biology and evolution · 2025Article
- RethinkingFrontiers in plant science · 2025Article
- Plant Nuclear Factor Y (NF-Y) Transcription Factors: Evolving Insights into Biological Functions and Gene Expansion.International journal of molecular sciences · 2024Review
- Article
- Orphan geneHorticulture research · 2024Article
- NF-YC15 transcription factor activates ethylene biosynthesis and improves cassava disease resistance.Plant biotechnology journal · 2024Article
- Genome-Wide Identification and Drought Stress Response Pattern of the NF-Y Gene Family inInternational journal of molecular sciences · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
Enhancing the nutritional quality and disease resistance of crops without sacrificing productivity is a key issue for developing varieties that are valuable to farmers and for simultaneously improving food security and sustainability. Expression of the Arabidopsis thaliana species-specific AtQQS (Qua-Quine Starch) orphan gene or its interactor, NF-YC4 (Nuclear Factor Y, subunit C4), has been shown to increase levels of leaf/seed protein without affecting the growth and yield of agronomic species. Here, we demonstrate that overexpression of AtQQS and NF-YC4 in Arabidopsis and soybean enhances resistance/reduces susceptibility to viruses, bacteria, fungi, aphids and soybean cyst nematodes. A series of Arabidopsis mutants in starch metabolism were used to explore the relationships between QQS expression, carbon and nitrogen partitioning, and defense. The enhanced basal defenses mediated by QQS were independent of changes in protein/carbohydrate composition of the plants. We demonstrate that either AtQQS or NF-YC4 overexpression in Arabidopsis and in soybean reduces susceptibility of these plants to pathogens/pests. Transgenic soybean lines overexpressing NF-YC4 produce seeds with increased protein while maintaining healthy growth. Pull-down studies reveal that QQS interacts with human NF-YC, as well as with Arabidopsis NF-YC4, and indicate two QQS binding sites near the NF-YC-histone-binding domain. A new model for QQS interaction with NF-YC is speculated. Our findings illustrate the potential of QQS and NF-YC4 to increase protein and improve defensive traits in crops, overcoming the normal growth-defense trade-offs.
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