Evidence map›Paper›PMID 29878357›Full record

ReviewJournal of surgical oncology2018

Checkpoint blockade in esophagogastric cancer.

Noah A Cohen, Vivian E Strong, Yelena Y Janjigian

Abstract readReview
In one paragraph

Review in Journal of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Immune Cell Homing Hydrogels for Cancer Immunotherapy.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noah A CohenDepartment of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.ORCID http://orcid.org/0000-0003-3947-2585
Vivian E StrongDepartment of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
Yelena Y JanjigianDepartment of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

There are few effective treatment options for metastatic esophagogastric adenocarcinomas after progression on second-line chemotherapy. Immune checkpoint blockade therapy is a promising treatment strategy for selected advanced esophagogastric cancer, and the PD-1 inhibitor pembrolizumab has recently been approved for metastatic or recurrent gastric or gastroesophageal junction cancer that has progressed beyond second-line systemic therapy. We review the current data supporting immune checkpoint blockade therapy in advanced esophagogastric adenocarcinoma.

Indexed as

AdenocarcinomaAntibodies, MonoclonalB7-H1 AntigenCTLA-4 AntigenEsophagogastric JunctionHumansImmunotherapyProgrammed Cell Death 1 ReceptorRandomized Controlled Trials as TopicStomach NeoplasmsAntibodies, MonoclonalB7-H1 AntigenCD274 protein, humanCTLA-4 AntigenCTLA4 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 Receptorcheckpoint inhibitorgastricgastroesophagealimmunotherapyPD-1

Identifiers

PMID29878357
PMCPMC7891842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.