Evidence map›Paper›PMID 29878220›Full record

SynthesisThe Journal of antimicrobial chemotherapy2018

Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure.

Ann Versporten, Inge C Gyssens, Céline Pulcini, Annelie A Monnier, Jeroen Schouten, Romina Milanic, Mirjana Stanic Benic, Gianpiero Tebano, Marion Le Maréchal, Veronica Zanichelli and 6 more

Abstract readSystematic ReviewConsensus Statement
In one paragraph

Synthesis in The Journal of antimicrobial chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. A Systematic Review of Dental Antibiotic Stewardship Interventions.Community dentistry and oral epidemiology · 2025
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  13. The preventative effects ofFrontiers in microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ann VersportenUniversity of Antwerp, Vaccine & Infectious Disease Institute (VAXINFECTIO), Laboratory of Medical Microbiology, Antwerp, Belgium.
Inge C GyssensDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Céline PulciniUniversité de Lorraine, APEMAC, F-54000 Nancy, France.
Annelie A MonnierDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Jeroen SchoutenScientific Center for Quality of Healthcare (IQ healthcare), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Romina MilanicDepartment of Clinical Pharmacology, University Hospital Rijeka and Medical Faculty, University of Rijeka, Rijeka, Croatia.
Mirjana Stanic BenicDepartment of Clinical Pharmacology, University Hospital Rijeka and Medical Faculty, University of Rijeka, Rijeka, Croatia.
Gianpiero TebanoUniversité de Lorraine, APEMAC, F-54000 Nancy, France.
Marion Le MaréchalUniversité de Lorraine, APEMAC, F-54000 Nancy, France.
Veronica ZanichelliInfection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Benedikt HuttnerInfection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Vera Vlahovic-PalcevskiDepartment of Clinical Pharmacology, University Hospital Rijeka and Medical Faculty, University of Rijeka, Rijeka, Croatia.
Herman GoossensUniversity of Antwerp, Vaccine & Infectious Disease Institute (VAXINFECTIO), Laboratory of Medical Microbiology, Antwerp, Belgium.
Marlies E HulscherScientific Center for Quality of Healthcare (IQ healthcare), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Niels AdriaenssensUniversity of Antwerp, Vaccine & Infectious Disease Institute (VAXINFECTIO), Laboratory of Medical Microbiology, Antwerp, Belgium.
DRIVE-AB WP1 group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use.

Indexed as

Anti-Bacterial AgentsDelivery of Health CareOutpatientsQuality Indicators, Health CareDelphi TechniqueEndpoint DeterminationGlobal HealthHumansInternationalitySurveys and QuestionnairesAnti-Bacterial Agents

Identifiers

PMID29878220
PMCPMC5989614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.