Evidence map›Paper›PMID 29878148›Full record

ReviewThe Journal of nutrition2018

Biomarkers of Nutrition for Development (BOND)-Iron Review.

Sean Lynch, Christine M Pfeiffer, Michael K Georgieff, Gary Brittenham, Susan Fairweather-Tait, Richard F Hurrell, Harry J McArdle, Daniel J Raiten

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Recent Advances in Research on Iron Metabolism, Ferritin, and Hepcidin.International journal of molecular sciences · 2026
    Pooled it
  2. Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024
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  9. Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2020
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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sean Lynch
Christine M PfeifferNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA.
Michael K GeorgieffDivision of Neonatology, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN.
Gary BrittenhamDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY.
Susan Fairweather-TaitDepartment of Nutrition, Norwich Medical School, Norwich Research Park, University of East Anglia, Norwich NR4 7JT, UK.
Richard F HurrellInstitute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland.
Harry J McArdleRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK.
Daniel J RaitenEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant knowledge regarding iron biology, public health implications, and the relative usefulness of currently available biomarkers of iron status from deficiency to overload. Approaches to assessing intake, including bioavailability, are also covered. The report also covers technical and laboratory considerations for the use of available biomarkers of iron status, and concludes with a description of research priorities along with a brief discussion of new biomarkers with potential for use across the spectrum of activities related to the study of iron in human health.The I-EP concluded that current iron biomarkers are reliable for accurately assessing many aspects of iron nutrition. However, a clear distinction is made between the relative strengths of biomarkers to assess hematological consequences of iron deficiency versus other putative functional outcomes, particularly the relationship between maternal and fetal iron status during pregnancy, birth outcomes, and infant cognitive, motor and emotional development. The I-EP also highlighted the importance of considering the confounding effects of inflammation and infection on the interpretation of iron biomarker results, as well as the impact of life stage. Finally, alternative approaches to the evaluation of the risk for nutritional iron overload at the population level are presented, because the currently designated upper limits for the biomarker generally employed (serum ferritin) may not differentiate between true iron overload and the effects of subclinical inflammation.

Indexed as

Anemia, Iron-DeficiencyNutritional StatusBiomarkersHumansInflammationIronIron DeficienciesBiomarkersIron

Identifiers

PMID29878148
PMCPMC6297556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.