Evidence map›Paper›PMID 29878111›Full record

ArticleHuman molecular genetics2018

Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Jonathan M Kocarnik, Melissa Richard, Misa Graff, Jeffrey Haessler, Stephanie Bien, Chris Carlson, Cara L Carty, Alexander P Reiner, Christy L Avery, Christie M Ballantyne and 25 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Distinct Roles of Myeloid- and Hepatocyte-PLA2G6 Deletion in Mice With Metabolic Dysfunction-Associated Steatotic Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 1 country.

Jonathan M KocarnikPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Melissa RichardBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Misa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Jeffrey HaesslerPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephanie BienPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chris CarlsonPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Cara L CartyPATH, Seattle, WA, USA.
Alexander P ReinerPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Christie M BallantyneDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Andrea Z LaCroixDepartment of Epidemiology, University of San Diego, San Diego, CA, USA.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Maja BarbalicDivision of Epidemiology, Human Genetics & Environmental Sciences, The University of Texas, Houston, TX, USA.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Weihong TangDivision of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, USA.
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Dongquan ChenDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Gregory A TalaveraDivision of Health Promotion and Behavioral Science, San Diego State University, San Diego, CA, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, USA.
Diana A Chirinos-MedinaDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Rocio PereiraDivision of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Katie NishimuraPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Petra BužkováDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Lyle G BestMissouri Breaks Industries Research, Inc., Eagle Butte, SD, USA.
José Luis AmbiteInformation Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Iona ChengDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Dana C CrawfordPopulation and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Lucia A HindorffDivision of Genomic Medicine, NHGRI, NIH, Bethesda, MD, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Gerardo HeissDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ulrike PetersPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Charles KooperbergPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Fred Hutch Cancer Center · USUniversity of North Carolina at Chapel Hill · USBrown Foundation · USUniversity of Minnesota · USUniversity of Southern California · USUniversity of Washington · USBaylor College of Medicine · USCase Western Reserve University · USMissouri Breaks Industries Research (United States) · USNational Human Genome Research Institute · USNorthwestern University · USProgram for Appropriate Technology in Health · USSan Diego State University · USStanford University · USThe University of Texas Health Science Center at Houston · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Hawaiʻi at Mānoa · USUniversity of Illinois Urbana-Champaign · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
VALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5M
NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Epidemiology of putative genuine genetic variant: The Women's Health IntiativeU01HG004790 · NHGRI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2008 to 2012
$9.9M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
A Genome-wide Association Study of Prostate Cancer in African AmericansU01CA136792 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2009 to 2011
$9.4M
Genetic Epidemiology of Causal Variants Across the Life CourseU01HG004803 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NORTH, KARI E. · 2008 to 2012
$9.0M
ARRA NIH HHSNCATS NIH HHS KL2 TR000421NCATS NIH HHS KL2 TR002317NCI NIH HHS P01 CA033619NCI NIH HHS P30 CA013148NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004801NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG004803NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL109301NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS HHSN271201100004CNIA NIH HHS R01 AG023629NIH HHS S10 OD020069WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

C-reactive protein (CRP) is a circulating biomarker indicative of systemic inflammation. We aimed to evaluate genetic associations with CRP levels among non-European-ancestry populations through discovery, fine-mapping and conditional analyses. A total of 30 503 non-European-ancestry participants from 6 studies participating in the Population Architecture using Genomics and Epidemiology study had serum high-sensitivity CRP measurements and ∼200 000 single nucleotide polymorphisms (SNPs) genotyped on the Metabochip. We evaluated the association between each SNP and log-transformed CRP levels using multivariate linear regression, with additive genetic models adjusted for age, sex, the first four principal components of genetic ancestry, and study-specific factors. Differential linkage disequilibrium patterns between race/ethnicity groups were used to fine-map regions associated with CRP levels. Conditional analyses evaluated for multiple independent signals within genetic regions. One hundred and sixty-three unique variants in 12 loci in overall or race/ethnicity-stratified Metabochip-wide scans reached a Bonferroni-corrected P-value <2.5E-7. Three loci have no (HACL1, OLFML2B) or only limited (PLA2G6) previous associations with CRP levels. Six loci had different top hits in race/ethnicity-specific versus overall analyses. Fine-mapping refined the signal in six loci, particularly in HNF1A. Conditional analyses provided evidence for secondary signals in LEPR, IL1RN and HNF1A, and for multiple independent signals in CRP and APOE. We identified novel variants and loci associated with CRP levels, generalized known CRP associations to a multiethnic study population, refined association signals at several loci and found evidence for multiple independent signals at several well-known loci. This study demonstrates the benefit of conducting inclusive genetic association studies in large multiethnic populations.

Indexed as

Genome-Wide Association StudyMetagenomicsCarbon-Carbon LyasesC-Reactive ProteinEnoyl-CoA HydrataseFemaleGlycoproteinsGroup VI Phospholipases A2HumansIntercellular Signaling Peptides and ProteinsLinkage DisequilibriumMaleMolecular EpidemiologyPolymorphism, Single NucleotideWhite PeopleCarbon-Carbon LyasesC-Reactive ProteinEnoyl-CoA HydrataseGlycoproteinsGroup VI Phospholipases A2HACL1 protein, humanIntercellular Signaling Peptides and ProteinsOLFML3 protein, humanPLA2G6 protein, human

Identifiers

PMID29878111
PMCPMC6077792
OpenAlexW2806801910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.