ArticleCerebral cortex (New York, N.Y. : 1991)2018
Revealing the Dynamic Modulations That Underpin a Resilient Neural Network for Semantic Cognition: An fMRI Investigation in Patients With Anterior Temporal Lobe Resection.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of the Right Language Network and the Multiple-Demand Network in Verbal Semantics: Insights From an Activation Likelihood Estimation Meta-Analysis of 561 Functional Neuroimaging Studies.Human brain mapping · 2025Pooled it
- The Role of the Anterior Temporal Lobe in Reading: An HD-tDCS Study.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Separating the forest from the palm trees: Individual variation in a presurgical language mapping task.NeuroImage. Clinical · 2026Article
- Article
- Left-hemisphere glioma drives systematic patterns of contralesional functional connectivity.Brain communications · 2025Article
- The neural basis of face pareidolia with human intracerebral recordings.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Drawing from name in semantic dementia reveals graded object knowledge representations in anterior temporal lobe.Memory & cognition · 2025Article
- The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Social-semantic knowledge in frontotemporal dementia and after anterior temporal lobe resection.Brain communications · 2024Article
- Distinct but cooperating brain networks supporting semantic cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Dynamics of Functional Networks for Syllable and Word-Level Processing.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Age-specificity and generalization of behavior-associated structural and functional networks and their relevance to behavioral domains.Human brain mapping · 2022Article
- The multidimensional nature of aphasia recovery post-stroke.Brain : a journal of neurology · 2022Article
- Review
- A tale of two gradients: differences between the left and right hemispheres predict semantic cognition.Brain structure & function · 2022Article
- Implicit, automatic semantic word categorisation in the left occipito-temporal cortex as revealed by fast periodic visual stimulation.NeuroImage · 2021Article
- The neural bases of resilient semantic system: evidence of variable neuro-displacement in cognitive systems.Brain structure & function · 2021Article
- Category-selective deficits are the exception and not the rule: Evidence from a case-series of 64 patients with ventral occipito-temporal cortex damage.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Homotopic redistribution of functional connectivity in insula-centered diffuse low-grade glioma.NeuroImage. Clinical · 2021Article
- Impaired naming performance in temporal lobe epilepsy: language fMRI responses are modulated by disease characteristics.Journal of neurology · 2021Article
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Abstract
One critical feature of any well-engineered system is its resilience to perturbation and minor damage. The purpose of the current study was to investigate how resilience is achieved in higher cognitive systems, which we explored through the domain of semantic cognition. Convergent evidence implicates the bilateral anterior temporal lobes (ATLs) as a conceptual knowledge hub. While bilateral damage to this region produces profound semantic impairment, unilateral atrophy/resection or transient perturbation has a limited effect. Two neural mechanisms might underpin this resilience to unilateral ATL damage: 1) the undamaged ATL upregulates its activation in order to compensate; and/or 2) prefrontal regions involved in control of semantic retrieval upregulate to compensate for the impoverished semantic representations that follow from ATL damage. To test these possibilities, 34 postsurgical temporal lobe epilepsy patients and 20 age-matched controls were scanned whilst completing semantic tasks. Pictorial tasks, which produced bilateral frontal and temporal activation, showed few activation differences between patients and control participants. Written word tasks, however, produced a left-lateralized activation pattern and greater differences between the groups. Patients with right ATL resection increased activation in left inferior frontal gyrus (IFG). Patients with left ATL resection upregulated both the right ATL and right IFG. Consistent with recent computational models, these results indicate that 1) written word semantic processing in patients with ATL resection is supported by upregulation of semantic knowledge and control regions, principally in the undamaged hemisphere, and 2) pictorial semantic processing is less affected, presumably because it draws on a more bilateral network.
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