Evidence map›Paper›PMID 29877916›Full record

ArticleJournal of thoracic imaging2019

Assessment of Interstitial Lung Disease Using Lung Ultrasound Surface Wave Elastography: A Novel Technique With Clinicoradiologic Correlates.

Ryan Clay, Brian J Bartholmai, Boran Zhou, Ronald Karwoski, Tobias Peikert, Thomas Osborn, Srinivasan Rajagopalan, Sanjay Kalra, Xiaoming Zhang

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of thoracic imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06844331 (ULtrasOund Applicability in the Assessment of Patients With fibRosing Interstitial Lung Disease), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06844331 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

ULtrasOund Applicability in the Assessment of Patients With fibRosing Interstitial Lung Disease (LORD): A Research Protocol of a Single Center, Real-life, Prospective Observational Study

TypeobservationalSponsorOdense University HospitalRan2024 to 2026Enrolled117ConditionsFibrosing Interstitial Lung Diseases, Thoracic UltrasoundArmsThoracic ultrasound
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  6. Observational
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  16. Quantitative Analysis and Automated Lung Ultrasound Scoring for Evaluating COVID-19 Pneumonia With Neural Networks.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  17. Article
  18. Review
  19. Grading Bleomycin-Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ryan ClayDepartments of Pulmonary and Critical Care Medicine.
Brian J BartholmaiRadiology.
Boran ZhouRadiology.
Ronald KarwoskiPhysiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.
Tobias PeikertDepartments of Pulmonary and Critical Care Medicine.
Thomas OsbornRheumatology.
Srinivasan RajagopalanRadiology.
Sanjay KalraDepartments of Pulmonary and Critical Care Medicine.
Xiaoming ZhangRadiology.
Pulmonary and Critical Care Associates · USCenter for Rheumatology · USMayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Measurement of surface lung tissue using ultrasoundR01HL125234 · NHLBI · MAYO CLINIC ROCHESTER · PI ZHANG, XIAOMING · 2015 to 2018
$1.5M
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS R01 HL125234
6 · The paper itself

Abstract

purposeOptimal strategies to detect early interstitial lung disease (ILD) are unknown. ILD is frequently subpleural in distribution and affects lung elasticity. Lung ultrasound surface wave elastography (LUSWE) is a noninvasive method of quantifying superficial lung tissue elastic properties. In LUWSE a handheld device applied at the intercostal space vibrates the chest at a set frequency, and the lung surface wave velocity is measured by an ultrasound probe 5 mm away in the same intercostal space. We explored LUWSE's ability to detect ILD and correlated LUSWE velocity with physiological, quantitative, and visual radiologic features of subjects with known ILD and of healthy controls. MATERIALS AND

methodsSeventy-seven subjects with ILD, mostly caused by connective tissue disease, and 19 healthy controls were recruited. LUSWE was performed on all subjects in 3 intercostal lung regions bilaterally. Comparison of LUSWE velocities pulmonary function testing, visual assessment, and quantitative analysis of recent computed tomographic imaging with Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER) software.

resultsSonographic velocities were higher in all lung regions for cases, with the greatest difference in the lateral lower lung. Median velocity in m/s was 5.84 versus 4.11 and 5.96 versus 4.27 (P<0.00001) for cases versus controls, left and right lateral lower lung zones, respectively. LUSWE velocity correlated negatively with vital capacity and positively with radiologist and CALIPER-detected interstitial abnormalities.

conclusionsLUSWE is a safe and noninvasive technique that shows high sensitivity to detect ILD and correlated with clinical, physiological, radiologic, and quantitative assessments of ILD. Prospective study in detecting ILD is indicated.

Indexed as

Elasticity Imaging TechniquesFemaleHumansLungLung Diseases, InterstitialMaleMiddle AgedReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID29877916
PMCPMC6281810
OpenAlexW2805848822

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.