ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2018
Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.bioRxiv : the preprint server for biology · 2026Article
- Population-scale analysis of frequency-dependent calcium dynamics in retinal ganglion cells under electric field stimulation.Scientific reports · 2026Article
- Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Characterization of Induced Current Density During Transcorneal Electrical Stimulation to Promote Neuroprotection in the Degenerating Retina.IEEE transactions on bio-medical engineering · 2024Article
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- Patient-specific computational models of retinal prostheses.Scientific reports · 2023Article
- Adaptive octree meshes for simulation of extracellular electrophysiology.Journal of neural engineering · 2023Article
- Inference of Electrical Stimulation Sensitivity from Recorded Activity of Primate Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Modeling extracellular stimulation of retinal ganglion cells: theoretical and practical aspects.Journal of neural engineering · 2023Article
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Retinal ganglion cells undergo cell type-specific functional changes in a computational model of cone-mediated retinal degeneration.Frontiers in neuroscience · 2023Article
- Editorial: Advances in bioelectronics and stimulation strategies for next generation neuroprosthetics.Frontiers in neuroscience · 2022Article
- Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study.Journal of neural engineering · 2021Article
- Modeling ON Cone Bipolar Cells for Electrical Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- A Computational Model Simulates Light-Evoked Responses in the Retinal Cone Pathway.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- The role of gap junctions in cell death and neuromodulation in the retina.Neural regeneration research · 2021Review
- Model-based comparison of current flow in rod bipolar cells of healthy and early-stage degenerated retina.Experimental eye research · 2021Article
- The effect of axon trajectory on retinal ganglion cell activation with epiretinal stimulation.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A computational model of electrical stimulation of the retina is proposed for investigating current waveforms used in prosthetic devices for restoring partial vision lost to retinal degenerative diseases. The model framework combines a connectome-based neural network model characterized by accurate morphological and synaptic properties with an admittance method model of bulk tissue and prosthetic electronics. In this model, the retina was computationally "degenerated," considering cellular death and anatomical changes that occur early in disease, as well as altered neural behavior that develops throughout the neurodegeneration and is likely interfering with current attempts at restoring vision. A resulting analysis of stimulation range and threshold of ON ganglion cells within the retina that are either healthy or in beginning stages of degeneration is presented for currently used stimulation waveforms, and an asymmetric biphasic current stimulation for subduing spontaneous firing to allow increased control over ganglion cell firing patterns in degenerated retina is proposed. Results show that stimulation thresholds of retinal ganglion cells do not notably vary after beginning stages of retina degeneration. In addition, simulation of proposed asymmetric waveforms showed the ability to enhance the control of ganglion cell firing via electrical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.