ArticleOptics express2018
High speed adaptive optics ophthalmoscopy with an anamorphic point spread function.
Article in Optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.Biomedical optics express · 2024Article
- Adaptive Optics Imaging of Inherited Retinal Disease.Cold Spring Harbor perspectives in medicine · 2023Review
- Powell lens-based line-field spectral domain optical coherence tomography system for cellular resolution imaging of biological tissue.Biomedical optics express · 2023Article
- High-speed measurement of retinal arterial blood flow in the living human eye with adaptive optics ophthalmoscopy.Optics letters · 2023Article
- Programmable, high-speed, adaptive optics partially confocal multi-spot ophthalmoscope using a digital micromirror device.Optics letters · 2023Article
- Extracting spacing-derived estimates of rod density in healthy retinae.Biomedical optics express · 2023Article
- Line-scanning SD-OCT forBiomedical optics express · 2022Article
- Adaptive optics wavefront correction using a damped transpose matrix of the influence function.Photonics research · 2022Article
- In vivo measurement of the lineal density of red blood cells in human retinal capillaries using high-speed adaptive optics ophthalmoscopy.Optics letters · 2021Article
- Optoretinography of individual human cone photoreceptors.Optics express · 2020Article
- High-speed adaptive optics line-scan OCT for cellular-resolution optoretinography.Biomedical optics express · 2020Article
- Quality improvement of adaptive optics retinal images using conditional adversarial networks.Biomedical optics express · 2020Article
- Bimorph deformable mirror-based adaptive optics scanning laser ophthalmoscope for the clinical design and performance.Neurophotonics · 2019Article
- Polynomial transformation model for frame-to-frame registration in an adaptive optics confocal scanning laser ophthalmoscope.Biomedical optics express · 2019Article
- NoninvasiveBiomedical optics express · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Retinal imaging working with a line scan mechanism and a line camera has the potential to image the eye with a near-confocal performance at the high frame rate, but this regime has difficulty to collect sufficient imaging light while adequately digitize the optical resolution in adaptive optics imaging. To meet this challenge, we have developed an adaptive optics line scan ophthalmoscope with an anamorphic point spread function. The instrument uses a high-speed line camera to acquire the retinal image and act as a confocal gate. Meanwhile, it employs a digital micro-mirror device to modulate the imaging light into a line of point sources illuminating the retina. The anamorphic mechanism ensures adequate digitization of the optical resolution and increases light collecting efficiency. We demonstrate imaging of the living human retina with cellular level resolution at a frame rate of 200 frames/second (FPS) with a digitization of 512 × 512 pixels over a field of view of 1.2° × 1.2°. We have assessed cone photoreceptor structure in images acquired at 100, 200, and 800 FPS in 2 normal human subjects, and confirmed that retinal images acquired at high speed rendered macular cone mosaic with improved measurement repeatability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.