ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Serum Inflammatory Markers in Patients with Adenovirus Respiratory Infection.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Bacterial-like inflammatory response in children with adenovirus leads to inappropriate antibiotic use: a multicenter cohort study.Infection · 2025Article
- High-level adenovirus-neutralizing antibodies plasma beneficial for adenovirus type 7 (Adv7) induced pediatric severe ARDS.Journal of virus eradication · 2025Article
- Adenoviral Pharyngitis in the Paediatric Emergency Department: The Pivotal Role of Rapid Antigenic Testing.Diagnostics (Basel, Switzerland) · 2025Article
- Immunological pathogenesis and treatment progress of adenovirus pneumonia in children.Italian journal of pediatrics · 2025Review
- Risk factor analysis and prediction model construction for severe adenovirus pneumonia in children.Italian journal of pediatrics · 2024Article
- Determinants of antibiotic prescription in children with adenovirus respiratory tract infections.European journal of pediatrics · 2024Article
- A new scoring in differential diagnosis: multisystem inflammatory syndrome or adenovirus infection?Turkish journal of medical sciences · 2024Article
- Severe pediatric adenoviral pneumonia combined with invasive pulmonary aspergillosis.BMC pulmonary medicine · 2023Article
- Analysis of the typing of adenovirus and its clinical characteristics in children with acute respiratory tract infection.BMC pediatrics · 2023Article
- Interleukin-6 serum levels are independently associated with severe adenovirus pneumonia in children: a cross-sectional study.Translational pediatrics · 2022Article
- Development of a model for early differentiation of adenovirus pneumonia fromTranslational pediatrics · 2022Article
- [Silencing CD46 and DSG2 in host A549 cells inhibits entry of human adenovirus type 3 and type 7 and reduces interleukin-8 release].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Causes of Lower Respiratory Tract Infections and the Use of Diagnostic Biomarkers in Blood Samples from Children in Hohhot, Inner Mongolia, China, Between July 2019 and June 2020.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Soluble Receptor for Advanced Glycation End Product Is Involved in the Inflammatory Response of Human Adenovirus-Infected Patients.Frontiers in microbiology · 2022Article
- Whole blood circular RNA hsa_circ_0002171 serves as a potential diagnostic biomarker for human adenovirus pneumonia in children.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- BV score differentiates viral from bacterial-viral co-infection in adenovirus PCR positive children.Frontiers in pediatrics · 2022Article
- Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults.Viruses · 2021Review
- The COVID-19 pandemic: an increased risk of rheumatoid arthritis.Future virology · 2021Review
- Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection.Virologica Sinica · 2021Article
- A preliminary nomogram constructed for early diagnosis of bronchitis obliterans in children with severe pneumonia.Translational pediatrics · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND The aim of this study was to characterize adenovirus-associated acute respiratory infection (ARI) and observe correlations between inflammatory markers and severity of human adenovirus type 7 (HAdV-7) infection, and to evaluate the potential of inflammatory markers to predict progression from upper-respiratory infection (URI) to adenovirus pneumonia (AdP). MATERIAL AND METHODS A total of 81 patients with adenovirus-associated ARI and confirmed HAdV-7 infection were enrolled. Cases were classified according to severity, as AdP and URI. Demographic and clinical data were collected retrospectively. Clinical features and serum inflammatory markers were evaluated and compared according to the severity of adenoviral infection. RESULTS We observed high-grade fever and strong inflammatory response in patients with HAdV-7-associated ARI. Procalcitonin (PCT), interleukin 6 (IL-6), and C-reactive protein concentrations were higher in patients with AdP than in those with URI. The mean erythrocyte sedimentation rate (ESR) was significantly higher in patients with AdP (p=0.008). Reduced serum prealbumin levels were observed in patients with HAdV-7 infection. In the analysis of URI to AdP prediction ability, areas under the curve (AUCs) for all inflammatory markers were <0.9. We found that 35.9% of pneumonia had ≥2 lobars of lung infiltrate and bilateral lung infiltrate, and 20% of patients with SP had pleural effusion and atelectasis. CONCLUSIONS IL-6 and ESR were associated with the severity of HAdV-7 respiratory infection. No inflammatory marker in our study predicted URI-to-AdP progression accurately. Lung infiltration and consolidation are common in HRCT in AdP. Multiple- or single-lobar/segment consolidation was most common in SP. SP progressed very quickly after onset.
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