Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient.

Kahori Morino, Yuichi Honma, Shinsuke Kumei, Tatsuyuki Watanabe, Keiichiro Kume, Ichiro Yoshikawa, Masaru Harada

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kahori MorinoThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Yuichi HonmaThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Shinsuke KumeiThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Tatsuyuki WatanabeThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Keiichiro KumeThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Ichiro YoshikawaThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Masaru HaradaThird Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cronkhite-Canada syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis, chronic diarrhea, ectodermal dysplasia, skin hyperpigmentation, hair loss and nail atrophy. Although the efficacy of corticosteroid and immunomodulatory agents has been demonstrated, no standard therapy regimen has been established, and the prognosis of CCS is still poor due to various complications. We here in report a CCS patient complicated with severe sepsis and disseminated intravascular coagulation who was successfully treated by combined modality therapies, including recombinant human soluble thrombomodulin.

Indexed as

Anti-Inflammatory AgentsCombined Modality TherapyDisseminated Intravascular CoagulationHumansImmunomodulationIntestinal PolyposisMaleMiddle AgedPrednisoloneRecombinant ProteinsSepsisThrombomodulinAnti-Inflammatory AgentsPrednisoloneRecombinant ProteinsThrombomodulinbacterial translocationCronkhite-Canada syndromedisseminated intravascular coagulationgastrointestinal polyposisrecombinant human soluble thrombomodulinsepsis

Identifiers

PMID29877275

DOI10.2169/internalmedicine.0633-17

PMCPMC6262703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.