ArticleBrain connectivity2018
Alteration of Diffusion-Tensor Magnetic Resonance Imaging Measures in Brain Regions Involved in Early Stages of Parkinson's Disease.
Article in Brain connectivity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD.NPJ Parkinson's disease · 2025Article
- White matter microstructural alterations and brain metabolism distributions in Parkinson's disease.Brain imaging and behavior · 2025Article
- Diffusion tensor metrics, motor and non-motor symptoms in de novo Parkinson's disease.Neuroradiology · 2024Article
- A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Utility of diffusion tensor imaging and generalized q-sampling imaging for predicting short-term clinical effect of deep brain stimulation in Parkinson's disease.Acta neurochirurgica · 2024Article
- Specific structural changes in Parkinson's disease-related olfactory dysfunction compared to others forms of olfactory dysfunction.Frontiers in neural circuits · 2024Article
- A circuit-based approach to modulate hypersexuality in Parkinson's disease.Psychiatry and clinical neurosciences · 2023Article
- Review
- White Matter Microstructural Alterations in Newly Diagnosed Parkinson's Disease: A Whole-Brain Analysis Using dMRI.Brain sciences · 2022Article
- Convolutional neural network optimizes the application of diffusion kurtosis imaging in Parkinson's disease.Brain informatics · 2021Article
- Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Utility of manual fractional anisotropy measurements in the management of patients with Parkinson disease: a feasibility study with a 1.5-T magnetic resonance imaging system.Acta radiologica open · 2021Article
- Changes of olfactory tract in Parkinson's disease: a DTI tractography study.Neuroradiology · 2021Article
- Self-Attention-Guided Recurrent Neural Network and Motion Perception for Intelligent Prediction of Chronic Diseases.Journal of healthcare engineering · 2021Article
- White matter microstructure relates to lassitude but not diagnosis in adolescents with depression.Brain imaging and behavior · 2020Article
- Diffusion Tensor Imaging in Parkinson's Disease and Parkinsonian Syndrome: A Systematic Review.Frontiers in neurology · 2020Review
- Combined Assessment of Diffusion Parameters and Cerebral Blood Flow Within Basal Ganglia in Early Parkinson's Disease.Frontiers in aging neuroscience · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Many nonmotor symptoms (e.g., hyposmia) appear years before the cardinal motor features of Parkinson's disease (PD). It is thus desirable to be able to use noninvasive brain imaging methods, such as magnetic resonance imaging (MRI), to detect brain abnormalities in early PD stages. Among the MRI modalities, diffusion-tensor imaging (DTI) is suitable for detecting changes in brain tissue structure due to neurological diseases. The main purpose of this study was to investigate whether DTI signals measured from brain regions involved in early stages of PD differ from those of healthy controls. To answer this question, we analyzed whole-brain DTI data of 30 early-stage PD patients and 30 controls using improved region of interest-based analysis methods. Results showed that (i) the fractional anisotropy (FA) values in the olfactory tract (connected with the olfactory bulb: one of the first structures affected by PD) are lower in PD patients than healthy controls; (ii) FA values are higher in PD patients than healthy controls in the following brain regions: corticospinal tract, cingulum (near hippocampus), and superior longitudinal fasciculus (temporal part). Experimental results suggest that the tissue property, measured by FA, in olfactory regions is structurally modulated by PD with a mechanism that is different from other brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.