Evidence map›Paper›PMID 29876881›Full record

ArticleMolecular neurobiology2019

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors.

David Aguinaga, Mireia Medrano, Arnau Cordomí, Mireia Jiménez-Rosés, Edgar Angelats, Mireia Casanovas, Ignacio Vega-Quiroga, Enric I Canela, Milos Petrovic, Katia Gysling and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Methamphetamine Blocks Adenosine AInternational journal of molecular sciences · 2021
    Article
  6. AInternational journal of molecular sciences · 2019
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

David AguinagaCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Mireia MedranoCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Arnau CordomíLaboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
Mireia Jiménez-RosésLaboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
Edgar AngelatsCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Mireia CasanovasCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Ignacio Vega-QuirogaDepartment of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Enric I CanelaCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Milos PetrovicSchool of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Katia GyslingDepartment of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Leonardo PardoLaboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
Rafael FrancoCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. rfranco123@gmail.com.ORCID http://orcid.org/0000-0003-2549-4919
Gemma NavarroCentro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. dimartts@hotmail.com.
Instituto de Salud Carlos III · ESUniversitat Autònoma de Barcelona · ESPontificia Universidad Católica de Chile · CLBiomedical Research Networking Center on Neurodegenerative Diseases · ESUniversity of Lancashire · GB

Funding

Secretaría de Estado de Investigación, Desarrollo e Innovación BFU2015-664405-R
6 · The paper itself

Abstract

Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (σ

Indexed as

AnimalsCalciumCells, CulturedCocaineCorpus StriatumDopamine Uptake InhibitorsGhrelinHEK293 CellsHumansMaleModels, MolecularNeuronsOleanolic AcidPhosphorylationRatsRats, Sprague-Dawley3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)esterCalciumCocaineDopamine Uptake InhibitorsGhrelinOleanolic AcidReceptors, sigmaSaponinsSigma-1 ReceptorCross-regulationDrug addictionFunctional selectivityG protein-coupled heteroreceptor complexNeuroendocrineReceptor heteromer

Identifiers

PMID29876881
OpenAlexW2806361016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.