Evidence map›Paper›PMID 29876677›Full record

ReviewCurrent oncology reports2018

Cardiac Toxicity from Breast Cancer Treatment: Can We Avoid This?

Jesse Caron, Anju Nohria

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jesse CaronCardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Anju NohriaCardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. anohria@bwh.harvard.edu.
Brigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewBreast cancer therapies, such as anthracyclines, trastuzumab, and chest irradiation, have well-established cardiotoxicities that lead to adverse outcomes. Here, we will review strategies to mitigate these cardiotoxicities. RECENT

findingsRecent consensus guidelines have established criteria for the identification and surveillance of breast cancer patients at increased risk of cardiotoxicity. Dose reduction, liposomal doxorubicin, and dexrazoxane may be considered in high-risk patients receiving anthracyclines. Anthracycline-free regimens should be considered in high-risk patients with HER-2+ breast cancer, if appropriate. Data to support the routine use of concomitant neurohormonal blockade or statins to prevent anthracycline- and trastuzumab-induced cardiomyopathy is not yet available. Strategies that minimize radiation dose to the heart such as deep inspiration and intensity-modulated radiation are recommended to prevent radiation-induced cardiotoxicity. Identification of high-risk patients, aggressive management of underlying cardiovascular risk factors, consideration of cardioprotective strategies, and routine surveillance of left ventricular function before and after therapy are recommended to reduce breast cancer treatment-associated cardiotoxicities.

Indexed as

CardiotoxicityCardiovascular DiseasesHeartAntineoplastic AgentsBreast NeoplasmsExerciseFemaleHumansRadiotherapyRisk FactorsAntineoplastic AgentsAnthracyclinesBiomarkersBreast cancerCardiotoxicityCardiovascular risk factorsDexrazoxaneDoseEchocardiographyExerciseNeurohormonal antagonistsPegylated liposomal doxorubicinPreventionRadiationStatinsSurveillanceTrastuzumab

Identifiers

PMID29876677
OpenAlexW2807460963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.