Evidence map›Paper›PMID 29876617›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2018

FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients.

E Incerti, S Broggi, A Fodor, M Cuzzocrea, A M Samanes Gajate, P Mapelli, C Fiorino, I Dell'Oca, M Pasetti, M Cattaneo and 4 more

Abstract readEvaluation Study
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Prognostic Value ofJournal of clinical medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

E IncertiUnit of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
S BroggiUnit of Medical Physics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
A FodorUnit of Radiotherapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M CuzzocreaUniversity of Milano-Bicocca, Milan, Italy.
A M Samanes GajateUnit of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
P MapelliUnit of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
C FiorinoUnit of Medical Physics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
I Dell'OcaUnit of Radiotherapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M PasettiUnit of Radiotherapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M CattaneoUnit of Medical Physics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
R CalandrinoUnit of Medical Physics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
L GianolliUnit of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
N Di MuzioUnit of Radiotherapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Maria PicchioUnit of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. picchio.maria@hsr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated.

methodsThis retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUV

resultsThe median OS was 9.1 months (range 0.0 - 69.6 months) after the end of HTT; 54/55 patients were dead at the last follow-up. BTV and TLG40, TLG50 and TLG60 were the most significant predictors of OS (p < 0.005). The median OS was 4.8 months in patients with MTV60 >5 cm

conclusionFDG PET-derived parameters effectively discriminated patients with a poor prognosis and may be helpful in the selection of MPM patients for salvage HTT.

Indexed as

AdultAgedAged, 80 and overDisease-Free SurvivalFemaleFluorodeoxyglucose F18HumansLung NeoplasmsMaleMesotheliomaMesothelioma, MalignantMiddle AgedPositron Emission Tomography Computed TomographyPredictive Value of TestsRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsFDG PET/CTHelical tomotherapyMalignant pleural mesotheliomaMTVSurvivalTLG

Identifiers

PMID29876617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.