Evidence map›Paper›PMID 29876358›Full record

ArticleFrontiers in cardiovascular medicine2018

Blood Pressure and Renal Responses to Orthostatic Stress Before and After Radiofrequency Renal Denervation in Patients with Resistant Hypertension.

Yann Vuignier, Eric Grouzmann, Olivier Muller, Nima Vakilzadeh, Mohamed Faouzi, Marc P Maillard, Salah D Qanadli, Michel Burnier, Grégoire Wuerzner

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01734096 (Effect of Lower Body Negative Pressure and Angiotensin II Receptor Blockade on Renal Hemodynamic, Neuro-hormonal and Tubular Response in Pre-hypertensive States), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01734096 phase4completednot on this map

Effect of Lower Body Negative Pressure and Angiotensin II Receptor Blockade on Renal Hemodynamic, Neuro-hormonal and Tubular Response in Pre-hypertensive States: a Randomized Controlled Trial.

TypeinterventionalSponsorPD Dr. Grégoire WuerznerRan2009 to 2016Enrolled78ConditionsHypertension, Obesity, White Coat Hypertension, Resistant HypertensionArmsLower body negative pressure (LBNP), Candesartan cilexetil
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yann VuignierService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Eric GrouzmannLaboratoire des Catécholamines et Peptides, Service de Biomédecine, Lausanne University Hospital, Lausanne, Switzerland.
Olivier MullerDepartment of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
Nima VakilzadehService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Mohamed FaouziInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Marc P MaillardService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Salah D QanadliCardio-Thoracic and Vascular Unit, Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.
Michel BurnierService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Grégoire WuerznerService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
University of Lausanne · CHInstitute of Social and Preventive Medicine · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsIn patients with resistant hypertension, renal denervation (RDN) studies have mainly focused their outcomes on blood pressure (BP). The aim of this study was to evaluate the long-term effect of RDN on neurohormonal profiles, renal hemodynamics and sodium excretion in a resting state and during stress induced by lower body negative pressure (LBNP). MATERIALS AND

methodsThis was a single center prospective observational study. Norepinephrine, plasma renin activity (PRA), glomerular filtration rate (GFR), renal plasma flow (RPF) and sodium excretion were measured in unstimulated conditions (rest) and after one hour of LBNP at three different time points: before (M0), one (M1) and twelve months (M12) after RDN.

resultsThirteen patients with resistant hypertension were included. In the resting state, no differences were observed in norepinephrine, PRA, sodium excretion and mean BP levels after RDN. GFR (78 ± 32 ml/min at M0 vs 66 ± 26 ml/min at M12 (

conclusionA decrease in GFR and filtration fraction was observed one year after RDN. In addition, our results suggest that RDN blunts not only the norepinephrine but also the mean BP, the GFR and the sodium excretion responses to an orthostatic stress one year after the intervention. REGISTRY NUMBER: NCT01734096.

Indexed as

glomerular filtration ratehypertensionlower body negative pressurerenal denervationrenal plasma flowsodium excretionsympathetic nervous system

Identifiers

PMID29876358
PMCPMC5975430
OpenAlexW2800663927

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.