Evidence map›Paper›PMID 29876309›Full record

ArticleTranslational lung cancer research2018

Rationale and early outcomes for the management of thymoma with proton therapy.

He J Zhu, Bradford S Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R Charles Nichols, Randal H Henderson, Catherine E Mercado

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational lung cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Proton Beam Therapy for Thymic Carcinoma with Pericardial Involvement.International journal of particle therapy · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Cardiotoxicity of mediastinal radiotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

He J ZhuDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
Bradford S HoppeDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
Stella FlampouriDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
Debbie LouisDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
John PirrisDepartment of Surgery, University of Florida, Jacksonville, FL, USA.
R Charles NicholsDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
Randal H HendersonDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
Catherine E MercadoDepartment of Radiation Oncology, University of Florida, Jacksonville, FL, USA.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiotherapy for thymic malignancies is technically challenging due to their close proximity to the heart, lungs, esophagus, and breasts, raising concerns about significant acute and late toxicities from conventional photon radiotherapy. Proton therapy (PT) may reduce the radiation dose to these vital organs, leading to less toxicity. We reviewed the dosimetry and outcomes among patients treated with PT for thymic malignancies at our institution.

methodsFrom January 2008 to March 2017, six patients with

resultsAt last follow-up (median follow-up, 2.6 years), there were two patients with recurrences, including metastatic disease in the patient treated definitively with chemotherapy and PT without surgery and a local-regional recurrence in the lung outside the proton field in one of the post-operative cases. No patients with

conclusionsPT achieved superior dose sparing to the heart, lung, and esophagus compared to IMRT for thymic malignancies. Patients treated with PT had few radiation-induced toxicities and similar survival compared to historic proton data.

Indexed as

outcomesparticle therapyradiation therapyradiotherapyThymoma

Identifiers

PMID29876309
PMCPMC5960651
OpenAlexW2801497869

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.