ArticleNeuroImage. Clinical2018
The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05444907 (Understanding Deep Brain Stimulation-induced Mania), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding Deep Brain Stimulation-induced Mania: Finding Potential Predictors to Optimize Treatment
Who cites it
25 citing papers in PubMed.
- A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder.Translational psychiatry · 2021Trial
- Age, emotional burden and deep brain stimulation electrode location shape Parkinson's disease quality of life.NPJ digital medicine · 2026Article
- An evolutionary view on the developing prefrontal cortex connectome and its psychopathological networks: Tract tracing and imaging studies linking two distant anthropoid species.Research square · 2026Article
- Subthalamic Deep Brain Stimulation: Mapping Non-Motor Outcomes to Structural Connections.Human brain mapping · 2025Article
- Pathological beta power increase in the subthalamic nucleus is absent in essential tremor.Brain communications · 2025Article
- Focused stimulation of dorsal versus ventral subthalamic nucleus enhances action-outcome learning in patients with Parkinson's disease.Brain communications · 2024Article
- Modeling impulsivity and risk aversion in the subthalamic nucleus with deep brain stimulation.Nature. Mental health · 2024Article
- Elevated Mood Induced by Subthalamic Nucleus Deep Brain Stimulation: A Video-Recorded Case Report.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Stimulation of non-motor subthalamic nucleus impairs selective response inhibition via prefrontal connectivity.Brain communications · 2023Article
- Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease: A Current Update on Preclinical Evidence.Current neuropharmacology · 2023Article
- Review
- Depression history modulates effects of subthalamic nucleus topography on neuropsychological outcomes of deep brain stimulation for Parkinson's disease.Translational psychiatry · 2022Article
- Predict initial subthalamic nucleus stimulation outcome in Parkinson's disease with brain morphology.CNS neuroscience & therapeutics · 2022Article
- Functional neuroanatomy of mania.Translational psychiatry · 2022Review
- Lateralized effects of deep brain stimulation in Parkinson's disease: evidence and controversies.NPJ Parkinson's disease · 2021Review
- The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus.Frontiers in neuroanatomy · 2021Article
- Non-motor Adverse Effects Avoided by Directional Stimulation in Parkinson's Disease: A Case Report.Frontiers in neurology · 2021Article
- Article
- The effect on deep brain stimulation of subthalamic nucleus and dopaminergic treatment in Parkinson disease.Medicine · 2020Article
- Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures.Communications biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation of the subthalamic nucleus for Parkinson's disease is an established advanced therapy that addresses motor symptoms and improves quality of life. However, it has also been associated with neuropsychiatric symptoms such as impulsivity and hypomania. When significant, these symptoms can be distressing, necessitating psychiatric intervention. However, a comprehensive analysis of neurocognitive and neuropsychiatric outcomes with reference to the site of subthalamic stimulation has not been undertaken. We examined this matter in a consecutive sample of 64 persons with Parkinson's disease undertaking subthalamic deep brain stimulation. Participants were assessed with a battery of neuropsychiatric instruments at baseline and at repeated postoperative intervals. A psychiatrist identified patients with emergent, clinically-significant symptoms due to stimulation. The site of the active electrode contact and a simulated volume of activated tissue were evaluated with reference to putative limbic, associative and motor subregions of the subthalamic nucleus. We studied anatomical correlates of longitudinal neuropsychiatric change and delineated specific subthalamic regions associated with neuropsychiatric impairment. We tested the ability of these data to predict clinically-significant symptoms. Subthalamic stimulation within the right associative subregion was associated with inhibitory errors on the Excluded Letter Fluency task at 6-weeks (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.