ArticleNeuroImage. Clinical2018
Disrupted grey matter network morphology in pediatric posttraumatic stress disorder.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Innovative Neuroimaging Biomarker Distinction of Major Depressive Disorder and Bipolar Disorder through Structural Connectome Analysis and Machine Learning Models.Diagnostics (Basel, Switzerland) · 2024Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- Resolving Heterogeneity in Posttraumatic Stress Disorder Using Individualized Structural Covariance Network Analysis.Depression and anxiety · 2024Article
- Individual-level brain morphological similarity networks: Current methodologies and applications.CNS neuroscience & therapeutics · 2023Review
- Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders.Genes · 2023Review
- Topological properties of individual gray matter morphological networks in identifying the preclinical stages of Alzheimer's disease: a preliminary study.Quantitative imaging in medicine and surgery · 2023Article
- Study on the changes of Structural Covariance Network in post-traumatic stress disorder.Brain imaging and behavior · 2022Article
- Article
- Using deep learning to classify pediatric posttraumatic stress disorder at the individual level.BMC psychiatry · 2021Article
- Gray matter structural networks related toeNeurologicalSci · 2021Article
- Disruption of gray matter morphological networks in patients with paroxysmal kinesigenic dyskinesia.Human brain mapping · 2021Article
- DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain.Psychiatry research. Neuroimaging · 2020Article
- The effect of jet lag on the human brain: A neuroimaging study.Human brain mapping · 2020Article
- Treatment of auditory verbal hallucinations with atypical antipsychotics in healthy individuals: an artificially controlled post-treatment report.The Journal of international medical research · 2020Article
- Large-scale white matter network reorganization in posttraumatic stress disorder.Human brain mapping · 2019Article
- Pediatric cancer, posttraumatic stress and fear-related neural circuitry.International journal of hematologic oncology · 2019Review
- Reduced local segregation of single-subject gray matter networks in adult PTSD.Human brain mapping · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Disrupted topological organization of brain functional networks has been widely observed in posttraumatic stress disorder (PTSD). However, the topological organization of the brain grey matter (GM) network has not yet been investigated in pediatric PTSD who was more vulnerable to develop PTSD when exposed to stress. Materials and methods: Twenty two pediatric PTSD patients and 22 matched trauma-exposed controls who survived a massive earthquake (8.0 magnitude on Richter scale) in Sichuan Province of western China in 2008 underwent structural brain imaging with MRI 8-15 months after the earthquake. Brain networks were constructed based on the morphological similarity of GM across regions, and analyzed using graph theory approaches. Nonparametric permutation testing was performed to assess group differences in each topological metric. Results: Compared with controls, brain networks of PTSD patients were characterized by decreased characteristic path length (P = 0.0060) and increased clustering coefficient (P = 0.0227), global efficiency (P = 0.0085) and local efficiency (P = 0.0024). Locally, patients with PTSD exhibited increased centrality in nodes of the default-mode (DMN), central executive (CEN) and salience networks (SN), involving medial prefrontal (mPFC), parietal, anterior cingulate (ACC), occipital and olfactory cortex and hippocampus. Conclusions: Our analyses of topological brain networks in children with PTSD indicate a significantly more segregated and integrated organization. The associations and disassociations between these grey matter findings and white matter (WM) and functional changes previously reported in this sample may be important for diagnostic purposes and understanding the brain maturational effects of pediatric PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.