ArticleNeuroImage. Clinical2018
Brain oscillations reveal impaired novelty detection from early stages of Parkinson's disease.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Beyond Technologies of Electroencephalography-Based Brain-Computer Interfaces: A Systematic Review From Commercial and Ethical Aspects.Frontiers in neuroscience · 2020Pooled it
- Cognition falters at ~4 Hz in Parkinson's disease.Trends in cognitive sciences · 2024Article
- Analysis of the Dynamics of Cognitive Impairments and Expression of Caspase Cascade Genes in Preclinical Stages of Parkinsonism Modeled Using α-Synuclein Oligomers.Bulletin of experimental biology and medicine · 2024Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Listening with an Ageing Brain - a Cognitive Challenge.Laryngo- rhino- otologie · 2023Review
- BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species.eNeuro · 2023Article
- Novelty-induced frontal-STN networks in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Cortical oscillatory dysfunction in Parkinson disease during movement activation and inhibition.PloS one · 2022Article
- New insights on the ventral attention network: Active suppression and involuntary recruitment during a bimodal task.Human brain mapping · 2021Article
- Neurophysiological investigation of auditory intensity dependence in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients.NPJ schizophrenia · 2021Article
- Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease.Frontiers in neurology · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of reliable biomarkers for early diagnosis and progression tracking of neurodegenerative diseases has become an important objective in clinical neuroscience in the last years. The P3a event-related potential, considered as the neurophysiological hallmark of novelty detection, has been shown to be reduced in Parkinson's disease (PD) and proposed as a sensitive measure for illness duration and severity. Our aim for this study was to explore for the first time whether impaired novelty detection could be observed through phase- and time-locked brain oscillatory activity at early PD. Twenty-seven patients with idiopathic PD at early stages (disease duration <5 years and Hoehn and Yahr stage <3) were included. A healthy control group (n = 24) was included as well. All participants performed an auditory involuntary attention task including frequent and deviant tones while a digital EEG was obtained. A neuropsychological battery was administered as well. Time-frequency representations of power and phase-locked oscillations and P3a amplitudes were compared between groups. We found a significant reduction of power and phase locking of slow oscillations (3-7 Hz) for deviant tones in the PD group compared to controls in the P3a time range (300-550 ms). Also, reduced modulation of late induced (not phase locked) alpha-beta oscillations (400-650 ms, 8-25 Hz) was observed in the PD group after deviant tones onset. The P3a amplitude was predicted by years of evolution in the PD group. Finally, while phase-locked slow oscillations were associated with task behavioral distraction effects, induced alpha-beta activity was related to cognitive flexibility performance. Our results show that novelty detection impairment can be identified in neurophysiological terms from very early stages of PD, and such impairment increases linearly as the disease progresses. Also, induced alpha-beta oscillations underlying novelty detection are related to executive functioning.
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