Evidence map›Paper›PMID 29876263›Full record

ArticleNeuroImage. Clinical2018

Hemispheric brain asymmetry differences in youths with attention-deficit/hyperactivity disorder.

P K Douglas, Boris Gutman, Ariana Anderson, C Larios, Katherine E Lawrence, Katherine Narr, Biswa Sengupta, Gerald Cooray, David B Douglas, Paul M Thompson and 2 more

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article
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  13. Review
  14. Article
  15. Article
  16. Article
  17. Inflammation, Dopaminergic Brain and Bilirubin.International journal of molecular sciences · 2023
    Review
  18. Handedness in ADHD: Meta-Analyses.Neuropsychology review · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

P K DouglasUniversity of Central Florida, IST, Modeling and Simulation Department, FL, USA; Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, CA, USA. Electronic address: pamelita@g.ucla.edu.
Boris GutmanImaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA.
Ariana AndersonSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, CA, USA.
C LariosUniversity of Central Florida, IST, Modeling and Simulation Department, FL, USA.
Katherine E LawrenceLaboratory of Neuroimaging, UCLA, CA, USA.
Katherine NarrLaboratory of Neuroimaging, UCLA, CA, USA.
Biswa SenguptaWellcome Trust Centre for Neuroimaging, 12 Queen Square, UCL, London, UK.
Gerald CoorayWellcome Trust Centre for Neuroimaging, 12 Queen Square, UCL, London, UK.
David B DouglasNuclear Medicine and Molecular Imaging, Stanford University School of Medicine, Palo Alto, CA, USA.
Paul M ThompsonImaging Genetics Center, USC Keck School of Medicine, Marina del Rey, CA, USA.
James J McGoughSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, CA, USA.
Susan Y BookheimerSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, CA, USA.
University of Central Florida · USWellcome Centre for Human Neuroimaging · GBStanford University · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHI, YONGGANG · 2012 to 2022
$14.1M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Structural and Functional Biomarkers of Attention-Deficit/Hyperactivity DisorderK01MH110645 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOUGLAS, PK · 2017 to 2020
$632k
Impact of Cumulative Genetic Risk on Brain Connectivity in ASDF31MH110140 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAWRENCE, KATHERINE E · 2016 to 2019
$110k
NCATS NIH HHS UL1 TR000124NIBIB NIH HHS P41 EB015922NICHD NIH HHS U54 HD087101NIMH NIH HHS F31 MH110140NIMH NIH HHS K01 MH110645
6 · The paper itself

Abstract

Introduction: Attention-deficit hyperactive disorder (ADHD) is the most common neurodevelopmental disorder in children. Diagnosis is currently based on behavioral criteria, but magnetic resonance imaging (MRI) of the brain is increasingly used in ADHD research. To date however, MRI studies have provided mixed results in ADHD patients, particularly with respect to the laterality of findings. Methods: We studied 849 children and adolescents (ages 6-21 y.o.) diagnosed with ADHD ( Results: DTI mean diffusivity AI group differences were significant in cingulum, inferior and superior longitudinal fasciculus, and cortico-spinal tracts ( Conclusions: Brain asymmetry measures allow each individual to serve as their own control, diminishing variability between individuals and when pooling data across sites. Asymmetry group differences were more significant than lateralized comparisons between ADHD and TD subjects across morphometric, volumetric, and DTI comparisons.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityBrainChildFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleOrgan SizeYoung Adult

Identifiers

PMID29876263
PMCPMC5988460
OpenAlexW2791600717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.