ArticleNeuroImage. Clinical2018
Disrupted modular organization of primary sensory brain areas in schizophrenia.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Functional connectivity signatures of NMDAR dysfunction in schizophrenia-integrating findings from imaging genetics and pharmaco-fMRI.Translational psychiatry · 2023Trial
- Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients.Translational psychiatry · 2026Article
- Relapse in alcohol dependence is characterized by disrupted modular brain network organization.European archives of psychiatry and clinical neuroscience · 2026Article
- Disrupted sensory interhemispheric synchronization in schizophrenia: a frequency-resolved VMHC analysis.Frontiers in psychiatry · 2026Article
- Characterization of Neural Network Connectivity and Modularity of Pigeon Nidopallium Caudolaterale During Target Detection.Animals : an open access journal from MDPI · 2025Article
- Dynamicity of brain network organization & their community architecture as characterizing features for classification of common mental disorders from whole-brain connectome.Translational psychiatry · 2024Article
- Diminished functional segregation and resilience are associated with symptomatic severity and cognitive impairments in schizophrenia: a large-scale study.General psychiatry · 2024Article
- Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network.Network neuroscience (Cambridge, Mass.) · 2024Article
- Neural substrates of verbal memory impairment in schizophrenia: A multimodal connectomics study.Human brain mapping · 2023Article
- Visual Hallucinations in Psychosis: The Curious Absence of the Primary Visual Cortex.Schizophrenia bulletin · 2023Article
- Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum.Schizophrenia bulletin · 2022Article
- Increased network centrality of the anterior insula in early abstinence from alcohol.Addiction biology · 2022Article
- The unbalanced reorganization of weaker functional connections induces the altered brain network topology in schizophrenia.Scientific reports · 2021Article
- Abberant inverted U-shaped brain pattern and trait-related retinal impairment in schizophrenia patients with combined auditory and visual hallucinations: a pilot study.Brain imaging and behavior · 2021Article
- Altered Spatial Organization of Dynamic Functional Network Associates With Deficient Sensory and Perceptual Network in Schizophrenia.Frontiers in psychiatry · 2021Article
- Brain Entropy During Aging Through a Free Energy Principle Approach.Frontiers in human neuroscience · 2021Article
- Functional connectome organization predicts conversion to psychosis in clinical high-risk youth from the SHARP program.Molecular psychiatry · 2020Article
- Antipsychotic agents deteriorate brain and retinal function in schizophrenia patients with combined auditory and visual hallucinations: A pilot study and secondary follow-up study.Brain and behavior · 2020Article
- Structural and Functional Connectivity of Visual Cortex in Schizophrenia and Bipolar Disorder: A Graph-Theoretic Analysis.Schizophrenia bulletin open · 2020Article
- Magnetic Resonance Imaging-Based Connectomics in First-Episode Schizophrenia: From Preclinical Study to Clinical Translation.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ) using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organization of brain connectivity networks. A few studies have shown altered distribution of connectivity within and between functional modules in SCZ patients, an indication of imbalanced functional segregation ad integration. However, no major alterations of modular organization have been reported in patients, and unambiguous identification of the neural substrates affected remains elusive. Recently, it has been demonstrated that current modularity analysis methods suffer from a fundamental and severe resolution limit, as they fail to detect features that are smaller than a scale determined by the size of the entire connectivity network. This resolution limit is likely to have hampered the ability to resolve differences between patients and controls in previous studies. Here, we apply Surprise, a novel resolution limit-free approach, to study the modular organization of resting state functional connectivity networks in a large cohort of SCZ patients and in matched healthy controls. Leveraging these important methodological advances we find new evidence of substantial fragmentation and reorganization involving primary sensory, auditory and visual areas in SCZ patients. Conversely, frontal and prefrontal areas, typically associated with higher cognitive functions, appear to be largely unaffected, with changes selectively involving language and speech processing areas. Our findings support the hypothesis that cognitive dysfunction in SCZ may involve deficits occurring already at early stages of sensory processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.