Evidence map›Paper›PMID 29876251›Full record

ArticleNeuroImage. Clinical2018

Impact of gender and genetics on emotion processing in Parkinson's disease - A multimodal study.

Julia Heller, Shahram Mirzazade, Sandro Romanzetti, Ute Habel, Birgit Derntl, Nils M Freitag, Jörg B Schulz, Imis Dogan, Kathrin Reetz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Sex Differences in the Speech of Persons With and Without Parkinson's Disease.American journal of speech-language pathology · 2024
    Article
  6. Article
  7. Article
  8. The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  9. Article
  10. Article
  11. Androgen Therapy in Neurodegenerative Diseases.Journal of the Endocrine Society · 2020
    Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Julia HellerDepartment of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Shahram MirzazadeDepartment of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Sandro RomanzettiDepartment of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Ute HabelDepartment of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Brain Structure-Function Relationships: Decoding the Human Brain at Systemic Levels, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Birgit DerntlDepartment of Psychiatry and Psychotherapy, University of Tübingen, Osianderstraße 24, Tübingen, Germany.
Nils M FreitagII. Institute of Physics B and JARA-FIT, RWTH Aachen University, Otto-Blumenthal-Straße, Aachen, Germany.
Jörg B SchulzDepartment of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Imis DoganDepartment of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Kathrin ReetzDepartment of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany. Electronic address: kreetz@ukaachen.de.
Forschungszentrum Jülich · DERWTH Aachen University · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•Understanding of the phenotypic heterogeneity of Parkinson's disease is needed.•Gender and genetics determine manifestation and progression of Parkinson's disease.•Altered emotion processing in Parkinson's disease is specific to male patients.•This is influenced by endocrinal and genetic factors in both genders.•This finding may impact the diagnosis and treatment of emerging clinical features.

Indexed as

Sex CharacteristicsAgedBrain MappingCatechol O-MethyltransferaseEmotionsEstradiolFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenParkinson DiseasePolymorphism, Single NucleotideProgesteroneCatechol O-MethyltransferaseCOMT protein, humanEstradiolOxygenProgesteroneSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanTestosteroneBAI, Beck anxiety inventoryBDI-II, Beck depression inventory version IIBFRT, Benton facial recognition testBOLD, blood‑oxygen-level dependentCOMT, catechol-O-methyltransferaseEmotionEPI, echo planar imagingfMRI, functional magnetic resonance imagingFunctional magnetic resonance imaging (fMRI)GenderGeneticsGM, gray matterHC, healthy controlsH&Y, Hoehn and Yahr rating scaleLEDD, levodopa equivalence daily doseMCI, mild cognitive impairmentMMSE, Mini-Mental State ExaminationMoCA, Montreal Cognitive AssessmentMRI, magnetic resonance imagingNMS, non-motor symptomsParkinson's disease (PD)PD, Parkinson's diseaseUPDRS, Unified Parkinson's disease rating scaleVBM, voxel-based morphometry

Identifiers

PMID29876251
PMCPMC5987844
OpenAlexW2793359594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.