Evidence map›Paper›PMID 29876234›Full record

ArticleBalkan journal of medical genetics : BJMG2017

Association of the MMP7 -181A>G Promoter Polymorphism with Early Onset of Chronic Obstructive Pulmonary Disease.

Tacheva T, Dimov D, Anastasov A, Zhelyazkova Y, Kurzawski M, Gulubova M, Drozdzik M, Vlaykova T

Open access · goldAbstract read
In one paragraph

Article in Balkan journal of medical genetics : BJMG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. The Genetics behind Sulfation: Impact on Airway Remodeling.Journal of personalized medicine · 2024
    Review
  3. Matrix Metalloproteinases in Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tacheva TDepartment of Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
Dimov DDepartment of Internal Medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
Anastasov ADepartment of Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
Zhelyazkova YDepartment of Internal Medicine, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
Kurzawski MDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Gulubova MDepartment of General and Clinical Pathology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
Drozdzik MDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Vlaykova TDepartment of Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
Trakia University · BGPomeranian Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by decreased air flow and is associated with abnormal chronic inflammation in the airways and extensive tissue remodeling. Matrix metalloproteinase-7 (MMP7) is produced primarily by the epithelium of many organs, including the lungs. A functional MMP7 -181A>G (rs11568818) promoter polymorphism influences the binding of nuclear regulatory proteins modulating the transcription of the gene. In this study, we genotyped 191 patients with COPD for

Indexed as

AgeChronic obstructive pulmonary disease (COPD)Matrix metalloproteinase-7 (MMP7)PolymorphismsRisk

Identifiers

PMID29876234
PMCPMC5972504
OpenAlexW2806896857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.