ReviewORAL & implantology
Pregnancy and periodontal disease: does exist a two-way relationship?
Review in ORAL & implantology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effect of Treating Periodontal Disease in Pregnant Women to Reduce the Risk of Preterm Birth and Low Birth Weight: An Umbrella Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Multiomics Analysis Reveals Significant Disparities in the Oral Microbiota and Metabolites Between Pregnant Women with and without Periodontitis.Infection and drug resistance · 2024Article
- Review
- Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Evaluation of the periodontal disease on oral microorganisms during pregnancy: A systematic review and meta-analysis.Journal of clinical and translational research · 2023Review
- How much do pregnant women know about the importance of oral health in pregnancy? Questionnaire-based survey.BMC pregnancy and childbirth · 2023Article
- Association between the Risk of Preterm Birth and Low Birth Weight with Periodontal Disease in Pregnant Women: An Umbrella Review.Dentistry journal · 2023Review
- The Impact of Progesterone and Estrogen on the Tooth Mobility.Medicina (Kaunas, Lithuania) · 2023Article
- Review
- Prevalence and Risk Factors for Periodontal Disease Among Women Attending Antenatal Care in Public Hospitals, Southwest Ethiopia, 2022: A Multicenter Cross-Sectional Study.Clinical, cosmetic and investigational dentistry · 2022Article
- Hormonal Fluctuations and Periodontal Status in Postmenopausal Women.International journal of dentistry · 2022Article
- The genetic determinants of oral diseases in Africa: The gaps should be filled.Frontiers in oral health · 2022Review
- Dysbiosis in salivary bacterial diversity of postpartum females and its association with oral health problems and APOs.Current research in microbial sciences · 2021Article
- Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update.Diagnostics (Basel, Switzerland) · 2021Review
- Pregnancy and Dentistry: A Literature Review on Risk Management during Dental Surgical Procedures.Dentistry journal · 2021Review
- Human milk microbiota in sub-acute lactational mastitis induces inflammation and undergoes changes in composition, diversity and load.Scientific reports · 2020Article
- Knowledge of oral health among family medicine physicians in Riyadh, Saudi Arabia 2020.Journal of family medicine and primary care · 2020Article
- Prevalence of and risk factors for periodontal disease among pregnant women in an antenatal care clinic in Khartoum, Sudan.BMC research notes · 2020Article
- Dental Phobia among Pregnant Women: Considerations for Healthcare Professionals.International journal of dentistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease (PD) is an inflammatory disease of the tissues supporting the teeth. PD affects 65 million adults over the age of 30 years in the USA, and worldwide 5 to 70% of adults. Women who develop PD during pregnancy, it's estimated 1 woman in 5, may have a higher risk of adverse pregnancy outcomes. PD during pregnancy starts by dental plaque and is increased by the action of pregnancy hormones. In order to study the effect of PD on adverse pregnancy outcomes, we have performed this narrative review summarising the current studies about the influence of PD on pregnancy. Periodontal pockets are a reservoir of oral microbiota. Modifications in oral microbiota may be considered as a potential mechanism for developing PD during pregnancy. PD is surely caused by bacteria, but the progression and worsening are due to a host immune response. The inflammation caused by PD is not limited to the oral cavity. It is hypothesized that episodes of bacteraemia and dissemination of endotoxins from periodontal pockets can induce the activation of the systemic immune response. In conclusion our narrative review shows that there's no relationship between PD and adverse pregnancy outcomes, and PD treatment during pregnancy does not confer a general protection against adverse pregnancy outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.