Evidence map›Paper›PMID 29876019›Full record

ArticleOncotarget2018

Lean body mass wasting and toxicity in early breast cancer patients receiving anthracyclines.

Federica Mazzuca, Concetta Elisa Onesti, Michela Roberto, Marco Di Girolamo, Andrea Botticelli, Paola Begini, Lidia Strigari, Paolo Marchetti, Maurizio Muscaritoli

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  5. Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  13. The Influence of Muscle Morphology on Oncological Outcomes: A Review.Journal of frailty, sarcopenia and falls · 2025
    Review
  14. Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  15. Article
  16. Hematologic toxicities, sarcopenia, and body composition change in breast cancer patients undergoing neoadjuvant chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Federica MazzucaDepartment of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Concetta Elisa OnestiDepartment of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Michela RobertoDepartment of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Marco Di GirolamoDepartment of Radiology, Sant'Andrea Hospital, Rome, Italy.
Andrea BotticelliDepartment of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Paola BeginiDepartment of Gastroenterology, Sant'Andrea Hospital, Rome, Italy.
Lidia StrigariLaboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.
Paolo MarchettiDepartment of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Maurizio MuscaritoliDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
CTO Andrea Alesini · ITSapienza University of Rome · ITExpert System (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcopenia refers to the reduction of both volume and number of skeletal muscle fibers. Lean body mass loss is associated with survival, quality of life and tolerance to treatment in cancer patients. The aim of our study is to analyse the association between toxicities and sarcopenia in early breast cancer patients receiving adjuvant treatment. MATERIALS AND

methodsBreast cancer patients who have received anthracycline-based adjuvant treatment were retrospectively enrolled. CT scan images performed before, during and after adjuvant chemotherapy were used to evaluate lean body mass at third lumbar vertebra level with the software Slice Omatic V 5.0.

results21 stage I-III breast cancer patients were enrolled. According to the skeletal muscle index at third lumbar vertebra cut-off ≤38.5 cm

conclusionLean body mass loss is associated with higher grade of toxicity in early breast cancer patients receiving adjuvant chemotherapy.

Indexed as

adjuvant chemotherapyanthracyclines toxicitybreast cancerlean body masssarcopenia

Identifiers

PMID29876019
PMCPMC5986630
OpenAlexW2804596040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.