Evidence map›Paper›PMID 29875996›Full record

ArticleOncotarget2018

Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.

Kyle M LaPak, Dennis C Vroom, Ayush A Garg, Xiangnan Guan, John L Hays, Jonathan W Song, Christin E Burd

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kyle M LaPakDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Dennis C VroomDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Ayush A GargDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA.
Xiangnan GuanDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
John L HaysDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Jonathan W SongDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA.
Christin E BurdDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

The overexpression and hyperactivity of p21-activated serine/threonine kinases (PAKs) is known to facilitate tumorigenesis; however, the contribution of cancer-associated

Indexed as

melanocytemelanomap21-activated kinasePAK7PKA

Identifiers

PMID29875996
PMCPMC5986637
OpenAlexW2803546985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.