ArticleOpen access Macedonian journal of medical sciences2018
Article in Open access Macedonian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Phenolic Profile of Seedless Ziziphus mauritiana Fruits and Leaves Extracts with In Vivo Antioxidant and Anti-Inflammatory Activities: Influence on Pro-Inflammatory Mediators.Chemistry & biodiversity · 2025Article
- Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional Medicine to Scientific Validation.Current nutrition reports · 2024Review
- A Literature Review of the Pharmacological Effects of Jujube.Foods (Basel, Switzerland) · 2024Review
- Article
- Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades.Journal of cellular and molecular medicine · 2023Article
- An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways.Metabolic brain disease · 2022Article
- Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis.Bioengineered · 2021Article
- Genus Ziziphus for the treatment of chronic inflammatory diseases.Saudi journal of biological sciences · 2021Review
- Research advances in bioactive components and health benefits of jujube (Journal of Zhejiang University. Science. B · 2021Review
- Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy.International journal of molecular sciences · 2021Review
- Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.Cell biochemistry and function · 2020Article
- Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation.Nutrients · 2020Article
- Indian Medicinal Plants and Formulations and Their Potential Against COVID-19-Preclinical and Clinical Research.Frontiers in pharmacology · 2020Review
- Effects of Iranian herbal ZofaAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
aimTo determine the in vivo antidiarrhoeal, antibacterial and anti-inflammatory activities of
methodThe fruit was macerated and extracted by 95% (v/v) ethanol. The antidiarrhoeal activity was evaluated using castor oil and
resultsEEZJ different doses did not show inhibitory activity against castor oil induced diarrhoea except for the higher (1200 mg/kg) dose. However, the frequency of defecation of stools and watery stool were reduced significantly when compared to control group (P ≤ 0.05 and P ≤ 0.01 respectively), resulted in overall 67% inhibition of diarrhoea. Our anti-inflammatory results demonstrated that EEZJ was able to inhibit the carrageenan-induced paw oedema in rats to a significant degree (p ≤ 0.05) and the paw volume and thickness of both left and right paw were affected compared to the negative control group.
conclusionEEZJ possesses antidiarrhoeal and antibacterial activity in a dose depending manner and may provide a pharmacological basis for its clinical use in diarrheal diseases. The activity may partially be due to the presence of betulinic acid and quercetin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.