ArticleEvolutionary applications2018
Heterozygosity-fitness correlation at the major histocompatibility complex despite low variation in Alpine ibex (
Article in Evolutionary applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Sarcoptic mange in wild ungulates in the European Alps - A systematic review.International journal for parasitology. Parasites and wildlife · 2023Review
- Ancient mitochondrial and modern whole genomes unravel massive genetic diversity loss during near extinction of Alpine ibex.Molecular ecology · 2022Article
- A robust sequencing assay of a thousand amplicons for the high-throughput population monitoring of Alpine ibex immunogenetics.Molecular ecology resources · 2022Article
- Positive selection on the MHC class II DLA-DQA1 gene in golden jackals (Canis aureus) from their recent expansion range in Europe and its effect on their body mass index.BMC ecology and evolution · 2021Article
- Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves (Evolutionary applications · 2021Article
- Article
- Bronchopulmonary Nematodes in Alpine Ibex: Shedding of First Stage Larvae Analyzed at the Individual Host Level.Frontiers in veterinary science · 2021Article
- Article
- Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak.Scientific reports · 2020Article
- Towards a more healthy conservation paradigm: integrating disease and molecular ecology to aid biological conservationJournal of genetics · 2020Review
- Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.Ecology and evolution · 2019Article
- Immunogenetic response of the bananaquit in the face of malarial parasites.BMC evolutionary biology · 2019Article
- "Balancing" balancing selection? Assortative mating at the major histocompatibility complex despite molecular signatures of balancing selection.Ecology and evolution · 2019Article
- Genetic Effects on Dispersion in Urinary Albumin and Creatinine in Three House Mouse (G3 (Bethesda, Md.) · 2019Article
- Heterozygosity-fitness correlation at the major histocompatibility complex despite low variation in Alpine ibex (Evolutionary applications · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crucial for the long-term survival of wild populations is their ability to fight diseases. Disease outbreaks can lead to severe population size reductions, which makes endangered and reintroduced species especially vulnerable. In vertebrates, the major histocompatibility complex (MHC) plays an important role in determining the immune response. Species that went through severe bottlenecks often show very low levels of genetic diversity at the MHC. Due to the known link between the MHC and immune response, such species are expected to be at particular risk in case of disease outbreaks. However, so far, only few studies have shown that low MHC diversity is correlated with increased disease susceptibility in species after severe bottlenecks. We investigated genetic variation at the MHC and its correlations with disease resistance and other fitness-related traits in Alpine ibex (
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