ArticleEuropean surgery : ACA : Acta chirurgica Austriaca2018
Indications for liver surgery in benign tumours.
Article in European surgery : ACA : Acta chirurgica Austriaca, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Systematic review on peri-operative lactate measurements to predict outcomes in patients undergoing liver resection.Journal of hepato-biliary-pancreatic sciences · 2020Pooled it
- Development and internal validation of a machine learning-based model for predicting postoperative complications after primary liver cancer resection.BMC surgery · 2026Article
- Radiomics Beyond Radiology: Literature Review on Prediction of Future Liver Remnant Volume and Function Before Hepatic Surgery.Journal of clinical medicine · 2025Review
- Multicenter Belgian prospective registry on minimally invasive and open liver surgery (BReLLS): experience from 1342 consecutive cases.Langenbeck's archives of surgery · 2025Article
- Reconsideration of the clinical management of hepatic hemangioma.World journal of gastrointestinal surgery · 2024Article
- Review
- Imaging features and management of focal liver lesions.World journal of radiology · 2024Review
- The Interplay between Perioperative Oxidative Stress and Hepatic Dysfunction after Human Liver Resection: A Prospective Observational Pilot Study.Antioxidants (Basel, Switzerland) · 2024Article
- Deep learning-assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver.European radiology · 2021Article
- Enlarged cystic artery.BMJ case reports · 2021Article
- Liver transplantation for rare liver diseases and rare indications for liver transplant.Translational gastroenterology and hepatology · 2021Review
- Extended liver resection including hypertrophy concept with portal venous embolisation for giant haemangioma. Too much surgery?Annals of hepato-biliary-pancreatic surgery · 2020Article
- Current concepts in ablative procedures for primary benign liver lesions: a step forward to minimize the invasiveness of treatment when deemed necessary.Medical oncology (Northwood, London, England) · 2020Review
- Article
- Pulmonary embolism due to hemangioma of segment I compressing the inferior vena cava: A Case Report.International journal of surgery case reports · 2020Article
- Robot-assisted enucleation of gigantic liver hemangiomas: Case series of 3 patients.International journal of surgery case reports · 2019Article
- HMGB1-induced endothelial cell pyroptosis is involved in systemic inflammatory response syndrome following radiofrequency ablation of hepatic hemangiomas.American journal of translational research · 2019Article
- Massive hepatic adenoma response to bland embolization: A case study.Radiology case reports · 2019Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManagement of benign liver tumours (BLT) is still object of discussion. Uncertainty still exists about patient selection, details of management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies for management of the most common benign solid tumours are recapitulated in this article. In addition, recommendations concerning practical issues are presented.
methodsAvailable data from peer-reviewed publications associated with the major controversies concerning treatment strategies of solid BLT were selected through a PubMed literature search.
resultsNon-randomized controlled trials, retrospective series and case reports dominate the literature. Conservative management in BLT is associated with low overall morbidity and mortality when applied in an appropriate patient population. Surgical intervention is indicated solely in the presence of progressive symptoms and suspicion of a malignant change. Linking abdominal symptoms to BLT should be interpreted with caution. No evidence is recorded for malignant transformation in haemangiomas and focal nodular hyperplasia (FNH), while a subgroup of hepatocellular adenoma (HCA) is associated with malignancy. Follow-up controls of BLT at 3 and 6 months should be sufficient to prove the stability of the lesion and its benign nature, after which no long-term follow-up is required routinely. However, many questions regarding this topic remain without definitive answers in the literature.
conclusionConservative management of solid BLT is a worldwide trend, but the available literature does not provide high-grade evidence for this strategy. Consequently, further prospective investigations on the unclear aspects are required. Hence, this article summarises practical highlights of therapeutic strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.