Evidence map›Paper›PMID 29875774›Full record

ArticleFrontiers in immunology2018

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During

Valentina Orlando, Marco P La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A Joosten, Carmela La Mendola, Simona Buccheri, Tom H M Ottenhoff, Francesco Dieli and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

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  8. Single-Cell Sequencing Reveals Functional Alterations in Tuberculosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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  11. Group AScience immunology · 2023
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  15. Review
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  20. Simvastatin Enhances the Immune Response AgainstFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Valentina OrlandoCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy.
Marco P La MannaCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy.
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.
Fabrizio PalmieriTranslational Research Unit, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.
Elena Lo PrestiCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy.
Simone A JoostenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Carmela La MendolaDepartment of Biopathology, University of Palermo, Palermo, Italy.
Simona BuccheriIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy.
Tom H M OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Francesco DieliCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy.
Nadia CaccamoCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy.
University of Palermo · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITLeiden University Medical Center · NLIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-cell-mediated immune responses play a fundamental role in controlling

Indexed as

ImmunophenotypingAdultAntigens, BacterialCD4 Lymphocyte CountCD4-Positive T-LymphocytesCytokinesDisease ProgressionFemaleHumansMaleMycobacterium tuberculosisPhenotypeReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsTuberculosisYoung AdultAntigens, BacterialCytokinesReceptors, Antigen, T-Cell, alpha-betaCD4 T-cellscytokinesMycobacterium tuberculosisnaive cellstuberculosis

Identifiers

PMID29875774
PMCPMC5974168
OpenAlexW2800626695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.