Evidence map›Paper›PMID 29875770›Full record

ReviewFrontiers in immunology2018

Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.

Manuel D Díaz-Muñoz, Martin Turner

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Manuel D Díaz-MuñozCentre de Physiopathologie Toulouse-Purpan, INSERM UMR1043/CNRS U5282, Toulouse, France.
Martin TurnerLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom.
Babraham Institute · GBCentre de Physiopathologie de Toulouse-Purpan · FR

Funding

Biotechnology and Biological Sciences Research Council BB/J00152X/1Biotechnology and Biological Sciences Research Council BB/J004472/1Wellcome Trust 200823/Z/16/Z
6 · The paper itself

Abstract

Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and translation are the other key steps for final gene expression, and they are all controlled by RNA-binding proteins (RBPs). Nowadays we have a deep understanding of how transcription factors control the immune system but recent evidences suggest that post-transcriptional regulation by RBPs is equally important for both development and activation of immune responses. Here, we review current knowledge about how post-transcriptional control by RBPs shapes our immune system and discuss the perspective of RBPs being the key players of a hidden immune cell epitranscriptome.

Indexed as

Gene Expression RegulationAnimalsEpigenesis, GeneticHomeostasisHumansImmune SystemImmunity, CellularImmunity, HumoralMyeloid CellsRNA-Binding ProteinsRNA Processing, Post-TranscriptionalT-LymphocytesRNA-Binding Proteinshumoral responseimmune cell activationimmune cell developmentimmune cell homeostasispost-transcriptional RNA regulationRNA binding proteinsT-cell mediated immunity

Identifiers

PMID29875770
PMCPMC5974052
OpenAlexW2804378101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.