Evidence map›Paper›PMID 29875750›Full record

ArticleFrontiers in microbiology2018

Extracellular Vesicles From the Helminth

Javier Roig, Maria L Saiz, Alicia Galiano, Maria Trelis, Fernando Cantalapiedra, Carlos Monteagudo, Elisa Giner, Rosa M Giner, M C Recio, Dolores Bernal and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Javier RoigÀrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Burjassot, Spain.
Maria L SaizVascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Alicia GalianoÀrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Burjassot, Spain.
Maria TrelisÀrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Burjassot, Spain.
Fernando CantalapiedraÀrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Burjassot, Spain.
Carlos MonteagudoDepartament de Patologia, Universitat de València, Burjassot, Spain.
Elisa GinerDepartament de Farmacologia, Universitat de València, Burjassot, Spain.
Rosa M GinerDepartament de Farmacologia, Universitat de València, Burjassot, Spain.
M C RecioDepartament de Farmacologia, Universitat de València, Burjassot, Spain.
Dolores BernalDepartament de Bioquímica i Biologia Molecular, Universitat de València, Burjassot, Spain.
Francisco Sánchez-MadridFacultad de Ciencias de la Salud, Universidad Europea de Valencia, Burjassot, Spain.
Antonio MarcillaÀrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Burjassot, Spain.
Universitat de València · ESSpanish National Centre for Cardiovascular Research · ESUniversidad Autónoma de Madrid · ES

Funding

European Research Council 294340
6 · The paper itself

Abstract

The complexity of the pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) has led to the quest of empirically drug therapies, combining immunosuppressant agents, biological therapy and modulators of the microbiota. Helminth parasites have been proposed as an alternative treatment of these diseases based on the hygiene hypothesis, but ethical and medical problems arise. Recent reports have proved the utility of parasite materials, mainly excretory/secretory products as therapeutic agents. The identification of extracellular vesicles on those secreted products opens a new field of investigation, since they exert potent immunomodulating effects. To assess the effect of extracellular vesicles produced by helminth parasites to treat ulcerative colitis, we have analyzed whether extracellular vesicles produced by the parasitic helminth

Indexed as

DSS-ulcerative colitisextracellular vesiclesFasciola hepaticainflammatory bowel disease

Identifiers

PMID29875750
PMCPMC5974114
OpenAlexW2802238345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.