ArticleFrontiers in physiology2018
Protein and the Adaptive Response With Endurance Training: Wishful Thinking or a Competitive Edge?
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The effectiveness of protein supplements on athletic performance and post-exercise recovery - a Bayesian multilevel meta-analysis of randomized controlled trials.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Effects of protein supplementation on body composition, physiological adaptations, and performance during endurance training: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- The effect of protein intake on athletic performance: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Muscle Protein Synthesis Responses Following Aerobic-Based Exercise or High-Intensity Interval Training with or Without Protein Ingestion: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The Effects of Dietary Protein Supplementation on Acute Changes in Muscle Protein Synthesis and Longer-Term Changes in Muscle Mass, Strength, and Aerobic Capacity in Response to Concurrent Resistance and Endurance Exercise in Healthy Adults: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
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- Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners.Journal of the International Society of Sports Nutrition · 2020Trial
- Protein Supplementation Does Not Augment Adaptations to Endurance Exercise Training.Medicine and science in sports and exercise · 2019Trial
- Current Perspectives on Protein Supplementation in Athletes: General Guidance and Special Considerations for Diabetes-A Narrative Review.Nutrients · 2025Review
- Enhancing Muscle Strength and Reducing Inflammation: The Combined Effects of Hydrolyzed House Cricket Protein Supplementation and Concurrent Training in Older Women.Food science & nutrition · 2025Article
- Tailored nutrition strategies for Paralympic athletes: addressing unique energy, nutrients, and hydration needs to enhance performance and health.Frontiers in nutrition · 2025Review
- A real-life snapshot: Evaluating exposures to low energy availability in male athletes from various sports.Physiological reports · 2024Article
- Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia.Cancers · 2024Review
- Whole Body Substrate Metabolism during Different Exercise Intensities with Special Emphasis on Blood Protein Changes in Trained Subjects-A Pilot Study.Journal of functional morphology and kinesiology · 2023Article
- Metabolic Predictors of Equine Performance in Endurance Racing.Metabolites · 2021Article
- Six Weeks of Aerobic Exercise in Untrained Men With Overweight/Obesity Improved Training Adaptations, Performance and Body Composition Independent of Oat/Potato or Milk Based Protein-Carbohydrate Drink Supplementation.Frontiers in nutrition · 2021Article
- Influence of Specific Collagen Peptides and Concurrent Training on Cardiometabolic Parameters and Performance Indices in Women: A Randomized Controlled Trial.Frontiers in nutrition · 2020Article
- Protein Supplementation in Sport: Source, Timing, and Intended Benefits.Current nutrition reports · 2019Review
- Whey Protein Isolate Supplementation While Endurance Training Does Not Alter Cycling Performance or Immune Responses at Rest or After Exercise.Frontiers in nutrition · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The significance of carbohydrates for endurance training has been well established, whereas the role of protein and the adaptive response with endurance training is unclear. Therefore, the aim of this perspective is to discuss the current evidence on the role of dietary protein and the adaptive response with endurance training. On a metabolic level, a single bout of endurance training stimulates the oxidation of several amino acids. Although the amount of amino acids as part of total energy expenditure during exercise is relatively low compared to other substrates (e.g., carbohydrates and fat), it may depress the rates of skeletal muscle protein synthesis, and thereby have a negative effect on training adaptation. A low supply of amino acids relative to that of carbohydrates may also have negative effects on the synthesis of capillaries, synthesis and turn-over of mitochondrial proteins and proteins involved in oxygen transport including hamoglobin and myoglobin. Thus far, the scientific evidence demonstrating the significance of dietary protein is mainly derived from research with resistance exercise training regimes. This is not surprising since the general paradigm states that endurance training has insignificant effects on skeletal muscle growth. This could have resulted in an underappreciation of the role of dietary protein for the endurance athlete. To conclude, evidence of the role of protein on endurance training adaptations and performance remains scarce and is mainly derived from acute exercise studies. Therefore, future human intervention studies must unravel whether dietary protein is truly capable of augmenting endurance training adaptations and ultimately performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.