ArticleAdvanced functional materials2018
Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.
Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Advances and Prospects in Using Induced Pluripotent Stem Cells for 3D Bioprinting in Cardiac Tissue Engineering.Reviews in cardiovascular medicine · 2025Pooled it
- Chitosan-Based Scaffolds for the Treatment of Myocardial Infarction: A Systematic Review.Molecules (Basel, Switzerland) · 2023Pooled it
- 3D Printable and Electrically Conductive Hyaluronic Acid Hydrogel for Cardiac and Vascular Tissue Engineering Applications.ACS omega · 2026Article
- From Enhancement to Elimination of Auxeticity by Inserting Multilayers of Diatomic Molecules into a Hard-Sphere Crystal.Materials (Basel, Switzerland) · 2026Article
- Mucin-Based Biomimetic Patches for Dynamic Heart Repair: Auxetic Structures and Translational Challenges.Cardiovascular engineering and technology · 2026Review
- A mechanically compliant MnORSC advances · 2026Article
- The roles of the microtubule cytoskeletal network in cardiac mechanobiology.Journal of cell science · 2026Review
- A self-locking conductive cardiac patch for immediate electrical integration with infarcted rat myocardium.Bioactive materials · 2026Article
- A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves.Advanced healthcare materials · 2026Article
- An Anisotropic and Stable-Conductance Patch for Mechanical-Electrical Coupling With Infarcted Myocardium.Exploration (Beijing, China) · 2025Article
- Spatially Programmable Electroadhesive Enables In Situ Site-Selective Functional Coupling.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Insights into Graphene Nanostructures, Fabrication Techniques, Mechanical, and Functional Behavior Characterization.Small science · 2025Review
- Clinical Application of 3D-Printed Custom Hemipelvic Prostheses With Re-Entrant Chiral Structure in Reconstruction After Pelvic Tumor Resection.Orthopaedic surgery · 2025Article
- Volumetric 3D Printing and Melt-Electrowriting to Fabricate Implantable Reinforced Cardiac Tissue Patches.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- 3D-Printed Flexible Conductive Hydrogel as a Wearable Platform for Dual Functions of Strain and Colorimetric Lactate Sensors.ACS applied materials & interfaces · 2025Article
- FromMaterials today. Bio · 2025Review
- 3D Printing of Auxetic Self-powered Mechanoluminescent Photonic Skins for Underwater Communication and Safety Monitoring.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Conductive biological materials for in vitro models: properties and sustainability implications.In vitro models · 2025Article
- Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair.Bioactive materials · 2025Review
- Realizing mechanical frustration at the nanoscale using DNA origami.Nature communications · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Excimer laser microablation is used to micropattern a re-entrant honeycomb (bow-tie) design into a chitosan-polyaniline composite. It is shown that the bow-tie design can produce patches with a wide range in mechanical strength and anisotropy, which can be tuned to match native heart tissue. Further, the auxetic patches are conductive and cytocompatible with murine neonatal cardiomyocytes in vitro. Ex vivo studies demonstrate that the auxetic patches have no detrimental effect on the electrophysiology of both healthy and MI rat hearts and conform better to native heart movements than unpatterned patches of the same material. Finally, the AuxCP applied in a rat MI model results in no detrimental effect on cardiac function and negligible fibrotic response after two weeks in vivo. This approach represents a versatile and robust platform for cardiac biomaterial design and could therefore lead to a promising treatment for MI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.