ArticleNature communications2018
Polysulfurating reagent design for unsymmetrical polysulfide construction.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- A concise synthesis of alkyl, aryl hydropersulfides.RSC advances · 2026Article
- Preparation of Unsymmetrical Disulfides via Catalytic Lewis Base Activation ofThe Journal of organic chemistry · 2026Article
- Cys-Lys stapling for unprotected peptides via tunable linkers.National science review · 2025Article
- Photocatalytic Bilateral Disulfuration of Thioethers Toward α-Sulfide Disulfides With Antibacterial Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Generation of perthiyl radicals for the synthesis of unsymmetric disulfides.Nature communications · 2025Article
- Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents.Chemical reviews · 2024Review
- SONature communications · 2024Article
- Kinetics of sulfur-transfer from titanocene (poly)sulfides to sulfenyl chlorides: rapid metal-assisted concerted substitution.Chemical science · 2024Article
- Radical approaches to C-S bonds.Nature reviews. Chemistry · 2023Review
- Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols.Nature communications · 2022Article
- Homocouplings of Sodium Arenesulfinates: Selective Access to Symmetric Diaryl Sulfides and Diaryl Disulfides.Molecules (Basel, Switzerland) · 2022Article
- Decatungstate-catalyzed radical disulfuration through direct C-H functionalization for the preparation of unsymmetrical disulfides.Nature communications · 2022Article
- Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.Nature communications · 2022Article
- Polymerization of Aniline Derivatives to Yield Poly[Macromolecules · 2021Article
- Photocatalytic three-component asymmetric sulfonylation via direct C(spNature communications · 2021Article
- Decarboxylative thiolation of redox-active esters to free thiols and further diversification.Nature communications · 2020Article
- Unsymmetrical polysulfidation via designed bilateral disulfurating reagents.Nature communications · 2020Article
- Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity.Bioorganic chemistry · 2020Article
- Steric and stereoscopic disulfide construction for cross-linkageChemical science · 2020Article
- Cu and Na contents regulate N uptake of Leymus chinensis growing in soda saline-alkali soil.PloS one · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From life science to material science, to pharmaceutical industry, and to food chemistry, polysulfides are vital structural scaffolds. However, there are limited synthetic methods for unsymmetrical polysulfides. Conventional strategies entail two pre-sulfurated cross-coupling substrates, R-S, with higher chances of side reactions due to the characteristic of sulfur. Herein, a library of broad-spectrum polysulfurating reagents, R-S-S-OMe, are designed and scalably synthesized, to which the R-S-S source can be directly introduced for late-stage modifications of biomolecules, natural products, and pharmaceuticals. Based on the hard and soft acids and bases principle, selective activation of sulfur-oxygen bond has been accomplished via utilizing proton and boride for efficient unsymmetrical polysulfuration. These polysulfurating reagents are highlighted with their outstanding multifunctional gram-scale transformations with various nucleophiles under mild conditions. A diversity of polysulfurated biomolecules, such as SS-(+)-δ-tocopherol, SS-sulfanilamide, SS-saccharides, SS-amino acids, and SSS-oligopeptides have been established for drug discovery and development.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.