ArticleNature2018
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 290 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
290citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
290 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efferocytosis and inflammation: a bibliometric and systematic analysis.Frontiers in medicine · 2025Pooled it
- Oxidized Phospholipids and Calcific Aortic Valvular Disease.Journal of the American College of Cardiology · 2024Pooled it
- Anti-Malondialdehyde Low-Density Lipoprotein Antibodies and Valvular Calcification: A Substudy of the SCOT-HEART Trial.Journal of the American Heart Association · 2025Trial
- The effects of colchicine on lipoprotein(a)- and oxidized phospholipid-associated cardiovascular disease risk.European journal of preventive cardiology · 2025Trial
- Effect of switching from tenofovir disoproxil fumarate to tenofovir alafenamide on lipid profiles in patients with hepatitis B.PloS one · 2022Trial
- Neutralization of pathogenic PC-OxPL by AAV-delivered scFv as a therapeutic strategy for amyotrophic lateral sclerosis.Molecular therapy. Advances · 2026Article
- Inflammation as a therapeutic target to improve kidney and cardiovascular outcomes.Nature reviews. Nephrology · 2026Review
- Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis.Nature cardiovascular research · 2026Article
- The Statin Floor Effect: a Mechanistic Framework for Residual Cardiovascular Risk.Cardiovascular drugs and therapy · 2026Review
- Targeting Inflammation in Atherosclerotic Cardiovascular Disease: Mechanisms and Emerging Therapies.Immunological reviews · 2026Review
- Role of Lipoprotein(a) in Aortic Valve Calcification: Inflammatory and Oxidative Mechanisms Involved.International journal of molecular sciences · 2026Review
- Grey matter degeneration during multiple sclerosis is linked to activation of neuronal necroptosis by oxidized phosphatidylcholines.Research square · 2026Article
- Age-related metabolomic signatures and stroke susceptibility in a population-based cohort.GeroScience · 2026Article
- The N-terminus of apolipoprotein B mediates the interaction of atherogenic lipoproteins with endothelial cells.The Journal of clinical investigation · 2026Article
- Lipid Peroxidation in Cancer Therapy: Molecular Mechanisms Involving Oxidative Stress, Cell Death, and Therapeutic Response.Molecules (Basel, Switzerland) · 2026Review
- The Relationship between Inflammation-Oxidative Stress and Lipoprotein (a) Levels in Healthy Subjects.Acta Cardiologica Sinica · 2026Article
- Oxidized Phosphatidylcholines Regulate Secretory Phospholipase AMolecules (Basel, Switzerland) · 2026Article
- Oxalate as an Emerging Contributor to Cardiovascular Disease: Links to Inflammation, Immunity, and Oxidative Stress.Nutrients · 2026Review
- E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.JCI insight · 2026Article
- SMASH Imaging: A Serial Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Strategy for High-Resolution Imaging Facilitates Dual-Polarity and MS2 Spatial Lipidomics on a Single Tissue Section.Analytical chemistry · 2026Article
230 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
22 authors.
Xuchu QueDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ming-Yow HungDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Calvin YeangDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ayelet GonenDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Thomas A ProhaskaDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Xiaoli SunDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Cody DiehlDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Antti MäättäA.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Dalia E GaddisLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Karen BowdenDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jennifer PattisonDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jeffrey G MacDonaldCenter for Human Nutrition, UT Southwestern Medical Center, Dallas, TX, USA.
Seppo Ylä-HerttualaA.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Pamela L MellonDepartment of Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Catherine C HedrickLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Klaus LeyLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Yury I MillerDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Christopher K GlassDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Kirk L PetersonDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Christoph J BinderDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Sotirios TsimikasDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Joseph L WitztumDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA. jwitztum@ucsd.edu.
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Dwayne G. Stupack · 1985 to 2026
$124.9MTRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALAN R. SALTIEL · 2003 to 2026
$40.4MROLE OF LIPOXYGENASES IN ATHEROGENESIS IN DIABETES MELLITUSP01HL055798 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HEDRICK, CATHERINE C · 1995 to 2016
$28.4MTranscriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4MProject 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5MThe Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2020
$7.5MAIBP therapyR35HL135737 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY · 2017 to 2023
$6.5MEXPERIMENTAL ENDOCRINOLOGY AND METABOLISMT32DK007044 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Amit Majithia · 1986 to 2026
$4.6MNEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUSR01DK044838 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1991 to 2011
$3.8MT Regulatory Lymphocytes, HDL Function, and AtherosclerosisR01HL112276 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HEDRICK, CATHERINE C, SORCI-THOMAS, MARY G · 2013 to 2016
$2.8MNCI NIH HHS P30 CA023100NHLBI NIH HHS P01 HL020948NHLBI NIH HHS P01 HL055798NHLBI NIH HHS P01 HL088093NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL086559NHLBI NIH HHS R01 HL112276NHLBI NIH HHS R01 HL119828NHLBI NIH HHS R35 HL135737NICHD NIH HHS P50 HD012303NICHD NIH HHS R01 HD082567NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK044838NIDDK NIH HHS T32 DK007044NIEHS NIH HHS P42 ES010337
Abstract
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes
Indexed as
AnimalsAortic Valve StenosisApoptosisAtherosclerosisCholesterolDisease ProgressionFatty LiverFemaleHypercholesterolemiaImmunoglobulin MInflammationLipoproteins, LDLMacrophages, PeritonealMiceMice, Inbred C57BLMice, TransgenicCholesterolImmunoglobulin MLipoproteins, LDLoxidized low density lipoproteinPhospholipidsPhosphorylcholineReceptors, LDLSingle-Chain Antibodies
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.