ArticleNature communications2018
Control of seed dormancy and germination by DOG1-AHG1 PP2C phosphatase complex via binding to heme.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- ASP1-mediated deSUMOylation of AL6 controls seed dormancy in Arabidopsis.Plant cell reports · 2026Article
- E3 ligase ATL17 is a key regulator of abscisic acid signaling that mediates AHG1 degradation in Arabidopsis thaliana.The New phytologist · 2026Article
- DOG1-Mediated Priming Followed by Environmentally Tunable Plasticity: A Two-Phase Model for Dormancy Establishment inProteomes · 2026Article
- AHG1-AFP interaction as a regulatory node in the ABA response during seed germination.The Plant journal : for cell and molecular biology · 2026Article
- RDO3 REPRESSOR 27, a new MED25 allele, regulates seed dormancy dependent on DOG1 and ABA pathways in Arabidopsis.Planta · 2026Article
- Dynamic and Basal Phosphorylation Landscapes of Abscisic Acid Signaling Revealed by Phosphoproteome Analysis in Arabidopsis.International journal of molecular sciences · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Combining RGB imaging with a two-stage deep learning method to reveal genetic variation of wheat sprouting traits.Plant phenomics (Washington, D.C.) · 2026Article
- Genome-wide identification and analysis of the Delay Of Germination 1 (DOG1) gene family in Brassica napus and its potential role in Manganese (Mn) stress response.BMC plant biology · 2026Article
- TaPP2C-a5 fine-tunes wheat seed dormancy and germination with a Triticeae-specific, alternatively spliced transcript.Journal of advanced research · 2026Article
- Re-examining potato dormancy in the context of commercial tuber storage.Journal of experimental botany · 2026Review
- Translating research on seed dormancy and germination from Arabidopsis to temperate cereals to control pre-harvest sprouting.Frontiers in plant science · 2026Review
- Pleiotropic SNPs and genes linked to enhanced seed longevity and vigor for climate resilient pearl millet production.Frontiers in plant science · 2026Article
- Metabolomic and transcriptomic analyses reveal the mechanisms underlyingFrontiers in genetics · 2026Article
- Genome-wide identification and functional characterization of PP2C genes in the wild relative of sweet potato Ipomoea trifida.BMC plant biology · 2025Article
- FL7 is an ancient ABA-independent inhibitor of PP2C-As regulating plant stress responses.Nature communications · 2025Article
- UBA2A regulates seed dormancy and the stability of chromatin-retained DOG1 messenger RNA.Journal of integrative plant biology · 2025Article
- The transcriptional landscape and dynamics regulating organ differentiation and dormancy in Curcuma alismatifolia.Plant physiology · 2025Article
- Evolutionary and functional diversification of the DOG gene family in wheat (Triticum aestivum L.) and their roles in seed dormancy.BMC genomics · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Abscisic acid (ABA) regulates abiotic stress and developmental responses including regulation of seed dormancy to prevent seeds from germinating under unfavorable environmental conditions. ABA HYPERSENSITIVE GERMINATION1 (AHG1) encoding a type 2C protein phosphatase (PP2C) is a central negative regulator of ABA response in germination; however, the molecular function and regulation of AHG1 remain elusive. Here we report that AHG1 interacts with DELAY OF GERMINATION1 (DOG1), which is a pivotal positive regulator in seed dormancy. DOG1 acts upstream of AHG1 and impairs the PP2C activity of AHG1 in vitro. Furthermore, DOG1 has the ability to bind heme. Binding of DOG1 to AHG1 and heme are independent processes, but both are essential for DOG1 function in vivo. Our study demonstrates that AHG1 and DOG1 constitute an important regulatory system for seed dormancy and germination by integrating multiple environmental signals, in parallel with the PYL/RCAR ABA receptor-mediated regulatory system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.