ArticleJournal of the Royal Society, Interface2018
Mathematical model of a serine integrase-controlled toggle switch with a single input.
Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications.Journal of the Royal Society, Interface · 2025Article
- Article
- Context-Dependent Stability and Robustness of Genetic Toggle Switches with Leaky Promoters.Life (Basel, Switzerland) · 2021Article
- A stochastic model of homeostasis: The roles of noise and nuclear positioning in deciding cell fate.iScience · 2021Article
- Stability and Robustness of Unbalanced Genetic Toggle Switches in the Presence of Scarce Resources.Life (Basel, Switzerland) · 2021Article
- A mechanistic model of the BLADE platform predicts performance characteristics of 256 different synthetic DNA recombination circuits.PLoS computational biology · 2020Article
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit.Engineering biology · 2020Article
- A single-input binary counting module based on serine integrase site-specific recombination.Nucleic acids research · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Dual-state genetic switches that can change their state in response to input signals can be used in synthetic biology to encode memory and control gene expression. A transcriptional toggle switch (TTS), with two mutually repressing transcription regulators, was previously used for switching between two expression states. In other studies, serine integrases have been used to control DNA inversion switches that can alternate between two different states. Both of these switches use two different inputs to switch ON or OFF. Here, we use mathematical modelling to design a robust one-input binary switch, which combines a TTS with a DNA inversion switch. This combined circuit switches between the two states every time it receives a pulse of a single-input signal. The robustness of the switch is based on the bistability of its TTS, while integrase recombination allows single-input control. Unidirectional integrase-RDF-mediated recombination is provided by a recently developed integrase-RDF fusion protein. We show that the switch is stable against parameter variations and molecular noise, making it a promising candidate for further use as a basic element of binary counting devices.
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