Evidence map›Paper›PMID 29875259›Full record

ArticleThe Journal of cell biology2018

Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules.

Jae-Geun Song, Matthew R King, Rui Zhang, Rachel S Kadzik, Akanksha Thawani, Sabine Petry

Abstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. The γ-TuRC: mastermind of multipurpose actions at the centrosome.Cellular and molecular life sciences : CMLS · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Mechanisms underlying spindle assembly and robustness.Nature reviews. Molecular cell biology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jae-Geun SongDepartment of Molecular Biology, Princeton University, Princeton, NJ.ORCID 0000-0002-0477-3903
Matthew R KingDepartment of Molecular Biology, Princeton University, Princeton, NJ.
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0003-3159-9565
Rachel S KadzikDepartment of Molecular Biology, Princeton University, Princeton, NJ.
Akanksha ThawaniDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ.
Sabine PetryDepartment of Molecular Biology, Princeton University, Princeton, NJ spetry@princeton.edu.ORCID 0000-0002-8537-9763

Funding

Building the Chromosome Segregation Machinery from ScratchDP2GM123493 · NIGMS · PRINCETON UNIVERSITY · PI PETRY, SABINE · 2016 to 2016
$2.4M
Determining the molecular mechanism of localizing and activating the gamma-tubulin ring complex (gamma-TuRC) at the centrosomeF32GM119195 · NIGMS · PRINCETON UNIVERSITY · PI KADZIK, RACHEL S · 2016 to 2017
$103k
NIGMS NIH HHS DP2 GM123493NIGMS NIH HHS F32 GM119195
6 · The paper itself

Abstract

Microtubules (MTs) must be generated from precise locations to form the structural frameworks required for cell shape and function. MTs are nucleated by the γ-tubulin ring complex (γ-TuRC), but it remains unclear how γ-TuRC gets to the right location. Augmin has been suggested to be a γ-TuRC targeting factor and is required for MT nucleation from preexisting MTs. To determine augmin's architecture and function, we purified

Indexed as

AnimalsCell Cycle ProteinsHumansMicrotubule-Associated ProteinsMicrotubule-Organizing CenterMicrotubulesProtein BindingProtein ConformationSpindle ApparatusTubulinXenopus laevisaugmin protein, humanCell Cycle ProteinsMicrotubule-Associated ProteinsTubulin

Identifiers

PMID29875259
PMCPMC6028527

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.