Evidence map›Paper›PMID 29875234›Full record

ArticleJournal of virology2018

Multiple Incursions and Recurrent Epidemic Fade-Out of H3N2 Canine Influenza A Virus in the United States.

Ian E H Voorhees, Benjamin D Dalziel, Amy Glaser, Edward J Dubovi, Pablo R Murcia, Sandra Newbury, Kathy Toohey-Kurth, Shuo Su, Divya Kriti, Harm Van Bakel and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Exposure of dogs to influenza A and B viruses.One health (Amsterdam, Netherlands) · 2026
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  17. Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021
    Article
  18. Canine and Feline Influenza.Cold Spring Harbor perspectives in medicine · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Ian E H Voorhees *Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Benjamin D Dalziel *Department of Integrative Biology, Oregon State University, Corvallis, Oregon, USA.
Amy GlaserDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Edward J DuboviDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Pablo R MurciaMedical Research Council-University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0002-4352-394X
Sandra NewburyDepartment of Medical Sciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.
Kathy Toohey-KurthDepartment of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, Wisconsin, USA.
Shuo SuMOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Divya KritiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0002-9357-5588
Harm Van BakelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Laura B GoodmanDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Christian LeuteneggerIdexx Laboratories, Inc., Molecular Diagnostics, West Sacramento, California, USA.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-9596-3552
Colin R ParrishBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA crp3@cornell.edu.ORCID https://orcid.org/0000-0002-1836-6655
Cornell University · USIcahn School of Medicine at Mount Sinai · USUniversity of Wisconsin–Madison · USIDEXX Laboratories (United States) · USNanjing Agricultural University · CNOregon State University · USThe University of Sydney · AUUniversity of Cambridge · GB

Funding

The Evolutionary and Biological Bases of Host Switching in VirusesR01GM080533 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PARRISH, COLIN R. · 2007 to 2019
$4.1M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
Adapting molecular food safety tests to alternative matricesU18FD005144 · FDA · CORNELL UNIVERSITY · PI GOODMAN, LAURA BRUNENGRABER · 2014 to 2019
$516k
FDA HHS U18 FD005144Medical Research Council MC_UU_12014/9NIAID NIH HHS HHSN272201400008CNIGMS NIH HHS R01 GM080533NIH HHS S10 OD018522
6 · The paper itself

Abstract

Avian-origin H3N2 canine influenza virus (CIV) transferred to dogs in Asia around 2005, becoming enzootic throughout China and South Korea before reaching the United States in early 2015. To understand the posttransfer evolution and epidemiology of this virus, particularly the cause of recent and ongoing increases in incidence in the United States, we performed an integrated analysis of whole-genome sequence data from 64 newly sequenced viruses and comprehensive surveillance data. This revealed that the circulation of H3N2 CIV within the United States is typified by recurrent epidemic burst-fade-out dynamics driven by multiple introductions of virus from Asia. Although all major viral lineages displayed similar rates of genomic sequence evolution, H3N2 CIV consistently exhibited proportionally more nonsynonymous substitutions per site than those in avian reservoir viruses, which is indicative of a large-scale change in selection pressures. Despite these genotypic differences, we found no evidence of adaptive evolution or increased viral transmission, with epidemiological models indicating a basic reproductive number,

Indexed as

EpidemicsAnimalsBasic Reproduction NumberDisease Transmission, InfectiousDog DiseasesDogsInfluenza A Virus, H3N2 SubtypeMolecular EpidemiologyOrthomyxoviridae InfectionsPhylogenySelection, GeneticSequence Analysis, DNAUnited StatesWhole Genome Sequencingcanine influenzaemerging virusinfluenzavirus evolutionvirus host adaptation

Identifiers

PMID29875234
PMCPMC6069211
OpenAlexW2805775483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.