Evidence map›Paper›PMID 29875224›Full record

ArticleNeurology2018

Spindle activity in young children with autism, developmental delay, or typical development.

Cristan A Farmer, Priyanka Chilakamarri, Audrey E Thurm, Susan E Swedo, Gregory L Holmes, Ashura W Buckley

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
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  6. Article
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  8. Article
  9. Article
  10. Article
  11. Sleep Spindle Abnormalities in Preschool Children With Autism Spectrum Disability: Insights From Nap Polysomnography.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  12. Observational
  13. Article
  14. Article
  15. Infant sleep spindle measures from EEG improve prediction of cerebral palsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cristan A FarmerFrom the National Institute of Mental Health (C.A.F., A.E.T., S.E.S., A.W.B.), NIH, Bethesda, MD; and Department of Neurological Sciences (P.C., G.L.H.), University of Vermont, Burlington.
Priyanka ChilakamarriFrom the National Institute of Mental Health (C.A.F., A.E.T., S.E.S., A.W.B.), NIH, Bethesda, MD; and Department of Neurological Sciences (P.C., G.L.H.), University of Vermont, Burlington.
Audrey E ThurmFrom the National Institute of Mental Health (C.A.F., A.E.T., S.E.S., A.W.B.), NIH, Bethesda, MD; and Department of Neurological Sciences (P.C., G.L.H.), University of Vermont, Burlington.
Susan E SwedoFrom the National Institute of Mental Health (C.A.F., A.E.T., S.E.S., A.W.B.), NIH, Bethesda, MD; and Department of Neurological Sciences (P.C., G.L.H.), University of Vermont, Burlington.
Gregory L HolmesFrom the National Institute of Mental Health (C.A.F., A.E.T., S.E.S., A.W.B.), NIH, Bethesda, MD; and Department of Neurological Sciences (P.C., G.L.H.), University of Vermont, Burlington.
Ashura W BuckleyFrom the National Institute of Mental Health (C.A.F., A.E.T., S.E.S., A.W.B.), NIH, Bethesda, MD; and Department of Neurological Sciences (P.C., G.L.H.), University of Vermont, Burlington. shu.buckley@nih.gov.
University of Vermont · US

Funding

Neurodevelopmental and Behavioral Phenotyping ZICMH002961 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THURM, AUDREY · 2017 to 2025
$12.6M
Sleep and Neurodevelopment ServiceZICMH002962 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BUCKLEY, ASHURA · 2017 to 2021
$6.1M
Treatment of Medical Conditions among Individuals with Autism Spectrum DisordersZIAMH002914 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SWEDO, SUSAN · 2009 to 2016
$3.8M
Network Abnormalities in AutismR03MH108915 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HOLMES, GREGORY L. · 2016 to 2017
$155k
Intramural NIH HHS ZIA MH002914NIMH NIH HHS R03 MH108915
6 · The paper itself

Abstract

objectiveTo determine whether spindle activity differs in young children with and without autism.

methodsWe investigated differences in spindle density, duration, and oscillatory features in 135 young children with autism, developmental delay without autism (DD), or typical development (TD) and secondarily assessed the dimensional relationship between spindle density and both cognitive ability and social functioning.

resultsCompared to TD, both spindle density (Cohen

conclusionIn a large cohort of young children with autism, spindle density was reduced compared to groups of age-matched children with DD or TD. Alterations in the maturational trajectory of spindles may provide valuable insight into the neurophysiologic differences related to behavior in disorders of neurodevelopment.

Indexed as

Autistic DisorderCase-Control StudiesChildChild, PreschoolDevelopmental DisabilitiesElectroencephalographyFemaleHumansIntelligence TestsMaleSleepSocialization

Identifiers

PMID29875224
PMCPMC6053112
OpenAlexW2805846514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.