ArticleBMJ (Clinical research ed.)2018
Clinical trial design and dissemination: comprehensive analysis of clinicaltrials.gov and PubMed data since 2005.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Incretin Dominance and Emerging Mechanisms in Obesity Pharmacotherapy: Insights from 275 Registered Clinical Trials (2019-2024).Therapeutic innovation & regulatory science · 2026Pooled it
- Time to publication for results of clinical trials.The Cochrane database of systematic reviews · 2024Pooled it
- PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2020 · on this mapPooled it
- The Current Landscape of Clinical Studies Focusing on Thyroid Cancer: A Comprehensive Analysis of Study Characteristics and Their Publication Status.Frontiers in endocrinology · 2020Pooled it
- Statistical Analysis Plan for the INTEnsive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial: A Stepped-Wedge Cluster Randomized Controlled Trial.Cerebrovascular diseases (Basel, Switzerland) · 2023Trial
- Trial
- Clinical Trials of Liposomes in Children's Anticancer Therapy: A Comprehensive Analysis of Trials Registered on ClinicalTrials.gov.International journal of nanomedicine · 2022Trial
- Characteristics of clinical trials for non-small cell lung cancer therapeutic vaccines registered on ClinicalTrials.gov.Frontiers in immunology · 2022Trial
- Global stagnation and misaligned priorities in BPH drug development: a 25-year landscape analysis of clinical trial registries.npj aging · 2026Article
- Association of Protocol Design-Related Factors With Enrollment Duration in Clinical Trials.Clinical and translational science · 2026Article
- Determinants of publication likelihood and timeliness for clinical studies.Journal of clinical and translational science · 2026Article
- Studies of Cannabinoid-Based Products in ClinicalTrials.gov: A Scoping Review.Pharmaceutical medicine · 2026Article
- Nanocarriers for Psoriasis Treatment: Insights from a Clinical Trial Registered on the Global Clinical Trials Registry Platform.International journal of nanomedicine · 2026Review
- Clinical outcome assessment trends in neuro-oncology trials.Neuro-oncology practice · 2025Article
- Non-traditional barriers to participation in pharmacologic chronic kidney disease clinical trials.BMC nephrology · 2025Article
- Systematic evaluation of patient-reported outcomes in clinical trials of digital health in cardiovascular diseases.NPJ digital medicine · 2025Article
- Public Disclosure of Results From Artificial Intelligence/Machine Learning Research in Health Care: Comprehensive Analysis of ClinicalTrials.gov, PubMed, and Scopus Data (2010-2023).Journal of medical Internet research · 2025Article
- Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial.JMIR research protocols · 2025Article
- Principal investigator gender and clinical trial success: analysis of over 3000 obstetrics and gynecology trials.AJOG global reports · 2025Article
- Clinical study status of diabetic gastrointestinal diseases.Frontiers in endocrinology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the distribution, design characteristics, and dissemination of clinical trials by funding organisation and medical specialty.
designCross sectional descriptive analysis. DATA SOURCES: Trial protocol information from clinicaltrials.gov, metadata of journal articles in which trial results were published (PubMed), and quality metrics of associated journals from SCImago Journal and Country Rank database. SELECTION CRITERIA: All 45 620 clinical trials evaluating small molecule therapeutics, biological drugs, adjuvants, and vaccines, completed after January 2006 and before July 2015, including randomised controlled trials and non-randomised studies across all clinical phases.
resultsIndustry was more likely than non-profit funders to fund large international randomised controlled trials, although methodological differences have been decreasing with time. Among 27 835 completed efficacy trials (phase II-IV), 15 084 (54.2%) had disclosed their findings publicly. Industry was more likely than non-profit trial funders to disseminate trial results (59.3% (10 444/17 627)
conclusionsTrial design and dissemination of results vary substantially depending on the type and size of funding institution as well as the disease area under study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.