Evidence map›Paper›PMID 29875191›Full record

ArticleJournal of clinical microbiology2018

"Pathogen Eradication" and "Emerging Pathogens": Difficult Definitions in Cystic Fibrosis.

Peter H Gilligan, Damian G Downey, J Stuart Elborn, Patrick A Flume, Sebastian Funk, Deirdre Gilpin, Timothy J Kidd, John McCaughan, B Cherie Millar, Philip G Murphy and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Colony morphotype variation inJournal of bacteriology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Peter H GilliganPathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA Peter.Gilligan@unchealth.unc.edu.
Damian G DowneyNorthern Ireland Regional Adult CF Centre, Belfast Health and Social Trust, Belfast, Northern Ireland, United Kingdom.
J Stuart ElbornCentre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom.
Patrick A FlumeDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Sebastian FunkCentre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, The London School of Hygiene & Tropical Medicine, London, United Kingdom.
Deirdre GilpinSchool of Pharmacy, Queen's University, Belfast, United Kingdom.
Timothy J KiddCentre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom.
John McCaughanDepartment of Medical Microbiology, The Royal Group of Hospitals, Belfast Health and Social Trust, Belfast, Northern Ireland, United Kingdom.
B Cherie MillarCentre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom.
Philip G MurphyDepartment of Medical Microbiology, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.
Jacqueline C RendallNorthern Ireland Regional Adult CF Centre, Belfast Health and Social Trust, Belfast, Northern Ireland, United Kingdom.
Michael M TunneySchool of Pharmacy, Queen's University, Belfast, United Kingdom.
John E MooreCentre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom.
Belfast Health and Social Care Trust · GBBelfast City Hospital · GBQueen's University Belfast · GBLondon School of Hygiene & Tropical Medicine · GBMedical University of South Carolina · USRoyal Brompton Hospital · GBTrinity College Dublin · IEUniversity of North Carolina Health Care · USUniversity of Queensland · AU

Funding

Medical Research Council MR/K021680/1
6 · The paper itself

Abstract

Infection is a common complication of cystic fibrosis (CF) airway disease. Current treatment approaches include early intervention with the intent to eradicate pathogens in the hope of delaying the development of chronic infection and the chronic use of aerosolized antibiotics to suppress infection. The use of molecules that help restore CFTR (cystic fibrosis transmembrane conductance regulator) function, modulate pulmonary inflammation, or improve pulmonary clearance may also influence the microbial communities in the airways. As the pipeline of these new entities continues to expand, it is important to define when key pathogens are eradicated from the lungs of CF patients and, equally important, when new pathogens might emerge as a result of these novel therapies.

Indexed as

Anti-Bacterial AgentsBacteriaChronic DiseaseCystic FibrosisDrug Resistance, Multiple, BacterialHumansLungRespiratory Tract InfectionsAnti-Bacterial Agentschronic infectioncystic fibrosisemerging pathogeneradicationMycobacterium abscessusPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID29875191
PMCPMC6113473
OpenAlexW2806874929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.