Evidence map›Paper›PMID 29875165›Full record

ArticleThe Journal of endocrinology2018

Critical role for the Tsc1-mTORC1 pathway in β-cell mass in Pdx1-deficient mice.

Juan Sun, Liqun Mao, Hongyan Yang, Decheng Ren

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Juan SunDepartment of MedicineThe University of Chicago, Chicago, Illinois, USA.
Liqun MaoDepartment of MedicineThe University of Chicago, Chicago, Illinois, USA.
Hongyan YangDepartment of GynecologyKey Research Laboratory of Gynecology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
Decheng RenDepartment of MedicineThe University of Chicago, Chicago, Illinois, USA decheng@uchicago.edu.
University of Chicago · USGuangzhou University · CN

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
NIDDK NIH HHS P30 DK020595
6 · The paper itself

Abstract

Mutations in the pancreatic duodenal homeobox (

Indexed as

AnimalsApoptosisCell CountCell ProliferationCells, CulturedCell SizeHomeodomain ProteinsInsulin-Secreting CellsMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutSignal TransductionTrans-ActivatorsTuberous Sclerosis Complex 1 ProteinHomeodomain ProteinsMechanistic Target of Rapamycin Complex 1pancreatic and duodenal homeobox 1 proteinTrans-ActivatorsTsc1 protein, mouseTuberous Sclerosis Complex 1 ProteinmTORC1Pdx1Tsc1β-cell massβ-cells

Identifiers

PMID29875165
PMCPMC6030447
OpenAlexW2805110406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.